Literature DB >> 20572274

Poly(β-cyclodextrin)/curcumin self-assembly: a novel approach to improve curcumin delivery and its therapeutic efficacy in prostate cancer cells.

Murali Mohan Yallapu1, Meena Jaggi, Subhash C Chauhan.   

Abstract

A novel PCD/CUR self-assembly approach for improved curcumin delivery to prostate cancer cells is described. The formation of PCD/CUR was confirmed using FTIR, DSC, TGA, and SEM/TEM, and their stability and solubility under physiological conditions was demonstrated. A mechanism for self-assembly is proposed. Intracellular uptake of the self-assemblies was studied by flow cytometry and immunofluorescence microscopy. The therapeutic efficacy was determined by cell proliferation and colony formation assays using C4-2, DU145 and PC3 prostate cancer cells. The results suggest that the PCD/CUR formulation could be a useful system for improving curcumin delivery and its therapeutic efficacy in prostate cancer.

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Year:  2010        PMID： 20572274     DOI： 10.1002/mabi.201000084

Source DB:  PubMed          Journal:  Macromol Biosci        ISSN： 1616-5187            Impact factor:   4.979


  21 in total

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Authors:  Jian Yin; Niel M Henriksen; David R Slochower; Michael K Gilson
Journal:  J Comput Aided Mol Des       Date:  2016-09-16       Impact factor: 3.686

Review 3.  Design and engineering of nanogels for cancer treatment.

Authors:  Murali Mohan Yallapu; Meena Jaggi; Subhash C Chauhan
Journal:  Drug Discov Today       Date:  2011-03-23       Impact factor: 7.851

4.  Photoclick Hydrogels Prepared from Functionalized Cyclodextrin and Poly(ethylene glycol) for Drug Delivery and in Situ Cell Encapsulation.

Authors:  Han Shih; Chien-Chi Lin
Journal:  Biomacromolecules       Date:  2015-06-03       Impact factor: 6.988

Review 5.  Molecular mechanisms of curcumin and its semisynthetic analogues in prostate cancer prevention and treatment.

Authors:  Brian C Jordan; Charlotta D Mock; Ramasamy Thilagavathi; Chelliah Selvam
Journal:  Life Sci       Date:  2016-03-24       Impact factor: 5.037

Review 6.  Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective.

Authors:  Jianxiang Zhang; Peter X Ma
Journal:  Adv Drug Deliv Rev       Date:  2013-05-11       Impact factor: 15.470

Review 7.  Therapeutic Applications of Curcumin Nanoformulations.

Authors:  Murali M Yallapu; Prashanth K Bhusetty Nagesh; Meena Jaggi; Subhash C Chauhan
Journal:  AAPS J       Date:  2015-09-03       Impact factor: 4.009

Review 8.  Perspectives on new synthetic curcumin analogs and their potential anticancer properties.

Authors:  Alok Vyas; Prasad Dandawate; Subhash Padhye; Aamir Ahmad; Fazlul Sarkar
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

9.  Curcumin nanomedicine: a road to cancer therapeutics.

Authors:  Murali M Yallapu; Meena Jaggi; Subhash C Chauhan
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

10.  Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer.

Authors:  Pallabita Chowdhury; Prashanth K B Nagesh; Sheema Khan; Bilal B Hafeez; Subhash C Chauhan; Meena Jaggi; Murali M Yallapu
Journal:  Acta Pharm Sin B       Date:  2017-12-10       Impact factor: 11.413
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