Farah Lone1, Abdul H Sultan, Ranee Thakar. 1. Department of Obstetrics and Gynaecology, Mayday University Hospital, 530 London Road, Croydon CR7 7YE, Surrey.
Abstract
INTRODUCTION AND HYPOTHESIS: To investigate the long-term safety and efficacy of transurethral injection of NASHA/Dx gel in women suffering from stress urinary incontinence (SUI). METHODS: Women with SUI treated with NASHA/Dx gel via the transurethral Implacer device at Mayday University Hospital between November 2002 and December 2003 had long-term outcomes of therapy evaluated. RESULTS: Eighteen of 21 were followed-up at mean 6.7 years (±SD 0.15). One year after the injection, 11/21 (52.3%) reported improvement. Of the women, 6/21 (28.5%) had a repeat injection and seven (33.3%) women experienced adverse events in the form of periurethral swellings. At 6.7 years, only one of seven women was continent of urine without requiring any further continence procedure, 44.4% were still experiencing SUI symptoms. Nine of 18 (42.8%) had undergone other continence procedures. CONCLUSION: Transurethral injection of NASHA/Dx gel in women with SUI is associated with complications and not effective in the long term.
INTRODUCTION AND HYPOTHESIS: To investigate the long-term safety and efficacy of transurethral injection of NASHA/Dx gel in women suffering from stress urinary incontinence (SUI). METHODS:Women with SUI treated with NASHA/Dx gel via the transurethral Implacer device at Mayday University Hospital between November 2002 and December 2003 had long-term outcomes of therapy evaluated. RESULTS: Eighteen of 21 were followed-up at mean 6.7 years (±SD 0.15). One year after the injection, 11/21 (52.3%) reported improvement. Of the women, 6/21 (28.5%) had a repeat injection and seven (33.3%) women experienced adverse events in the form of periurethral swellings. At 6.7 years, only one of seven women was continent of urine without requiring any further continence procedure, 44.4% were still experiencing SUI symptoms. Nine of 18 (42.8%) had undergone other continence procedures. CONCLUSION: Transurethral injection of NASHA/Dx gel in women with SUI is associated with complications and not effective in the long term.
Authors: Paul Abrams; Linda Cardozo; Magnus Fall; Derek Griffiths; Peter Rosier; Ulf Ulmsten; Philip van Kerrebroeck; Arne Victor; Alan Wein Journal: Neurourol Urodyn Date: 2002 Impact factor: 2.696