Literature DB >> 20571365

Neurosteroid vitamin D system as a nontraditional drug target in neuropsychopharmacology.

Adam Stewart1, Keith Wong, Jonathan Cachat, Marco Elegante, Tom Gilder, Sopan Mohnot, Nadine Wu, Anna Minasyan, Pentti Tuohimaa, Allan V Kalueff.   

Abstract

Vitamin D is becoming increasingly recognized as a nontraditional drug target for different brain pathologies. Although widely known for their role in calcium metabolism, vitamin D and its receptor have been linked to several brain disorders, including cognitive decline, epilepsy, affective disorders, and schizophrenia. Here we discuss mounting evidence, and parallel recent clinical and animal behavioral, genetic and pharmacological data to emphasize the emerging role of the neurosteroid vitamin D system in brain function.

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Year:  2010        PMID： 20571365     DOI： 10.1097/FBP.0b013e32833c850f

Source DB:  PubMed          Journal:  Behav Pharmacol        ISSN： 0955-8810            Impact factor:   2.293


  13 in total

1.  Vitamin D Insufficiency and Cognitive Function Trajectories in Older Adults: The Rancho Bernardo Study.

Authors:  Gail A Laughlin; Donna Kritz-Silverstein; Jaclyn Bergstrom; Emilie T Reas; Simerjot K Jassal; Elizabeth Barrett-Connor; Linda K McEvoy
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

2.  Neuroprotective effects of vitamin D alone or in combination with lamotrigine against lithium-pilocarpine model of status epilepticus in rats.

Authors:  Amal M Mahfoz; Ali F Abdel-Wahab; Mohamed A Afify; Naiyer Shahzad; Ibrahim A A Ibrahim; Naser A ElSawy; Ghazi A Bamagous; Saeed S Al Ghamdi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-07-07       Impact factor: 3.000

3.  Effect of Different Vitamin D Levels on Cognitive Function in Aged Mice After Sevoflurane Anesthesia.

Authors:  Jialei Zhang; Xiaoling Zhang; Yongyan Yang; Jun Zhao; Wenqing Hu; Yonghao Yu
Journal:  Front Aging Neurosci       Date:  2022-06-10       Impact factor: 5.702

4.  Role of vitamin D3 in treatment of lumbar disc herniation--pain and sensory aspects: study protocol for a randomized controlled trial.

Authors:  Mahsa Sedighi; Ali Haghnegahdar
Journal:  Trials       Date:  2014-09-25       Impact factor: 2.279

Review 5.  Vitamin D3 for the Treatment of Epilepsy: Basic Mechanisms, Animal Models, and Clinical Trials.

Authors:  Kevin Pendo; Christopher M DeGiorgio
Journal:  Front Neurol       Date:  2016-12-08       Impact factor: 4.003

6.  Effects of Chronic Vitamin D₃ Hormone Administration on Anxiety-Like Behavior in Adult Female Rats after Long-Term Ovariectomy.

Authors:  Julia Fedotova; Svetlana Pivina; Anastasia Sushko
Journal:  Nutrients       Date:  2017-01-03       Impact factor: 5.717

7.  25-Hydroxyvitamin D3 Deficiency Independently Predicts Cognitive Impairment in Patients with Systemic Lupus Erythematosus.

Authors:  Sen Hee Tay; Chung Shun Ho; Roger Chun-Man Ho; Anselm Mak
Journal:  PLoS One       Date:  2015-12-04       Impact factor: 3.240

8.  Neurochemical effects of chronic administration of calcitriol in rats.

Authors:  Pei Jiang; Li-Hong Zhang; Hua-Lin Cai; Huan-De Li; Yi-Ping Liu; Mi-Mi Tang; Rui-Li Dang; Wen-Ye Zhu; Ying Xue; Xin He
Journal:  Nutrients       Date:  2014-12-22       Impact factor: 5.717

9.  Exploratory Metabolomics Profiling in the Kainic Acid Rat Model Reveals Depletion of 25-Hydroxyvitamin D3 during Epileptogenesis.

Authors:  Svenja Heischmann; Kevin Quinn; Charmion Cruickshank-Quinn; Li-Ping Liang; Rick Reisdorph; Nichole Reisdorph; Manisha Patel
Journal:  Sci Rep       Date:  2016-08-16       Impact factor: 4.379

10.  Protective effects of 1α,25-Dihydroxyvitamin D3 on cultured neural cells exposed to catalytic iron.

Authors:  Francesca Uberti; Vera Morsanuto; Claudio Bardelli; Claudio Molinari
Journal:  Physiol Rep       Date:  2016-06
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