BACKGROUND: Little is known about detection of genital human papilloma virus (HPV) types in women's fingertips. The study objectives were to determine the presence of genital HPV types in fingertip samples and the agreement between fingertip and genital samples for detecting HPV. METHODS: At triannual visits, genital and fingertip samples were collected from female university students and tested for 37 HPV genotypes by PCR-based assay. Type-specific concordance between paired fingertip and genital samples was evaluated using kappa statistics for percent positive agreement (kappa+). Paired samples with type-specific concordant fingertip and genital results were selected for variant characterization. RESULTS: A total of 357 fingertip samples were collected from 128 women. HPV prevalence in fingertip samples was 14.3%. Although percent positive agreement between fingertips and genitals for detecting type-specific HPV was low (17.8%; kappa+ = 0.17; 95% confidence interval, 0.10-0.25), 60.4% of type-specific HPV detected in the fingertips was detected in a concurrent genital sample. All but one of 28 paired concordant samples were positive for the same type-specific variant in the fingertip and genital sample. Redetection of HPV types at the subsequent visit was more common in genital samples (73.3%) than in fingertip samples (14.5%; P < 0.001). CONCLUSIONS: Detection of genital HPV types in the fingertips was not uncommon. Although impossible to distinguish between deposition of DNA from the genitals to the fingertips and true fingertip infection, the rarity of repeat detection in the fingertips suggests that deposition is more common. IMPACT: Finger-genital transmission is plausible but unlikely to be a significant source of genital HPV infection.
BACKGROUND: Little is known about detection of genital human papilloma virus (HPV) types in women's fingertips. The study objectives were to determine the presence of genital HPV types in fingertip samples and the agreement between fingertip and genital samples for detecting HPV. METHODS: At triannual visits, genital and fingertip samples were collected from female university students and tested for 37 HPV genotypes by PCR-based assay. Type-specific concordance between paired fingertip and genital samples was evaluated using kappa statistics for percent positive agreement (kappa+). Paired samples with type-specific concordant fingertip and genital results were selected for variant characterization. RESULTS: A total of 357 fingertip samples were collected from 128 women. HPV prevalence in fingertip samples was 14.3%. Although percent positive agreement between fingertips and genitals for detecting type-specific HPV was low (17.8%; kappa+ = 0.17; 95% confidence interval, 0.10-0.25), 60.4% of type-specific HPV detected in the fingertips was detected in a concurrent genital sample. All but one of 28 paired concordant samples were positive for the same type-specific variant in the fingertip and genital sample. Redetection of HPV types at the subsequent visit was more common in genital samples (73.3%) than in fingertip samples (14.5%; P < 0.001). CONCLUSIONS: Detection of genital HPV types in the fingertips was not uncommon. Although impossible to distinguish between deposition of DNA from the genitals to the fingertips and true fingertip infection, the rarity of repeat detection in the fingertips suggests that deposition is more common. IMPACT: Finger-genital transmission is plausible but unlikely to be a significant source of genital HPV infection.
Authors: Rachel L Winer; James P Hughes; Qinghua Feng; Sandra O'Reilly; Nancy B Kiviat; King K Holmes; Laura A Koutsky Journal: N Engl J Med Date: 2006-06-22 Impact factor: 91.245
Authors: Rachel L Winer; Qinghua Feng; James P Hughes; Mujun Yu; Nancy B Kiviat; Sandra O'Reilly; Laura A Koutsky Journal: Sex Transm Dis Date: 2007-06 Impact factor: 2.830
Authors: Jeffrey M Partridge; James P Hughes; Qinghua Feng; Rachel L Winer; Bethany A Weaver; Long-Fu Xi; Michael E Stern; Shu-Kuang Lee; Sandra F O'Reilly; Stephen E Hawes; Nancy B Kiviat; Laura A Koutsky Journal: J Infect Dis Date: 2007-09-13 Impact factor: 5.226
Authors: Rachel L Winer; Shu-Kuang Lee; James P Hughes; Diane E Adam; Nancy B Kiviat; Laura A Koutsky Journal: Am J Epidemiol Date: 2003-02-01 Impact factor: 4.897
Authors: Rachel L Winer; James P Hughes; Qinghua Feng; Sandra O'Reilly; Nancy B Kiviat; Laura A Koutsky Journal: J Infect Dis Date: 2009-03-15 Impact factor: 5.226
Authors: Brenda Y Hernandez; Lynne R Wilkens; Xuemei Zhu; Pamela Thompson; Katharine McDuffie; Yurii B Shvetsov; Lori E Kamemoto; Jeffrey Killeen; Lily Ning; Marc T Goodman Journal: Emerg Infect Dis Date: 2008-06 Impact factor: 6.883
Authors: Anna R Giuliano; Alan G Nyitray; Aimée R Kreimer; Christine M Pierce Campbell; Marc T Goodman; Staci L Sudenga; Joseph Monsonego; Silvia Franceschi Journal: Int J Cancer Date: 2014-07-26 Impact factor: 7.396
Authors: Beibei Lu; Raphael P Viscidi; Yougui Wu; Alan G Nyitray; Luisa L Villa; Eduardo Lazcano-Ponce; Roberto J Carvalho da Silva; Maria Luiza Baggio; Manuel Quiterio; Jorge Salmerón; Danelle C Smith; Martha Abrahamsen; Mary Papenfuss; Anna R Giuliano Journal: Cancer Epidemiol Biomarkers Prev Date: 2012-07-03 Impact factor: 4.254
Authors: Marcia L Shew; Bree Weaver; Wanzhu Tu; Yan Tong; J Dennis Fortenberry; Darron R Brown Journal: J Infect Dis Date: 2012-12-13 Impact factor: 5.226
Authors: Tsung-chieh Jane Fu; James P Hughes; Qinghua Feng; Ayaka Hulbert; Stephen E Hawes; Long Fu Xi; Stephen M Schwartz; Joshua E Stern; Laura A Koutsky; Rachel L Winer Journal: Sex Transm Dis Date: 2015-12 Impact factor: 2.830