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Literature DB >> 205704

Perhexiline induces generalized lipidosis in rats.

Abstract

Administration of perhexiline (Pexide) to rats causes generalized occurrence of lamellated and crystalloid cytoplasmic inclusions which resemble those described in patients with perhexiline-induced polyneuropathy. It is concluded that perhexiline being an amphiphilic cationic compound is a potent inducer of generalized lipidosis.

Entities: Chemical Disease Species

Mesh：

Substances：
Piperidines
Perhexiline

Year: 1978 PMID： 205704 DOI： 10.1007/bf01489178

Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173

7 in total

Review 1. Drug-induced phospholipidoses. II. Tissue distribution of the amphiphilic drug chlorphentermine.

Authors: H Lüllmann; R Lüllmann-Rauch; O Wassermann
Journal: CRC Crit Rev Toxicol Date: 1975-11

2. Chlophentermine-induced abnormalcytoplasmic inclusions in peripheral blood cells of rats and guinea pigs.

Authors: R Lüllmann-Rauch
Journal: Toxicol Appl Pharmacol Date: 1975-04 Impact factor: 4.219

3. Polyneuropathy after perhexiline maleate therapy.

Authors: F Lhermitte; M Fardeau; F Chedru; J Mallecourt
Journal: Br Med J Date: 1976-05-22

4. [Electron microscopic study of nerve, muscle and skin lesions induced by perhexiline maleate (author's transl)].

Authors: J M Mussini; J J Hauw; R Escourolle
Journal: Acta Neuropathol Date: 1977-04-29 Impact factor: 17.088

5. Liver ganglioside storage after perhexiline maleate.

Authors: A Lageron; R Poupon; P P de Saint-Maur; V G Lévy
Journal: Lancet Date: 1977-02-26 Impact factor: 79.321

Review 6. [Drug-induced phospholipid storage disease].

Authors: H Lüllmann; R Lüllmann-Rauch; O Wassermann
Journal: Dtsch Med Wochenschr Date: 1973-08-31 Impact factor: 0.628

7. Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs.

Authors: R Lüllmann-Rauch; D Scheid
Journal: Virchows Arch B Cell Pathol Date: 1975-11-21

7 in total

8 in total

1. Effects of Pexid on liver cell cultures. Ultrastructural and histoenzymological studies.

Authors: A Lageron; J Scotto; M Gautier
Journal: Eur J Clin Pharmacol Date: 1981 Impact factor: 2.953

2. Effects of several lipidosis-inducing drugs upon the area postrema and adjacent medullary nuclei of adult rats. II. Axonal alternations.

Authors: W Frisch; R Lüllmann-Rauch
Journal: Acta Neuropathol Date: 1981 Impact factor: 17.088

Review 3. Metabolic approaches to the treatment of ischemic heart disease: the clinicians' perspective.

Authors: Andrew A Wolff; Heschi H Rotmensch; William C Stanley; Roberto Ferrari
Journal: Heart Fail Rev Date: 2002-04 Impact factor: 4.214

4. Effects of several lipidosis-including drugs upon the area postrema and adjacent medullary nuclei of adult rats. I. Alterations is perikarya and dendrites.

Authors: W Frisch; R Lüllmann-Rauch
Journal: Acta Neuropathol Date: 1980 Impact factor: 17.088