Literature DB >> 7495377

Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite.

Y Yamanaka1, E Sakamoto, Y Sakuma, H Uno, T Koyama, Y Izawa, K Fujiwara.   

Abstract

Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory neurons, satellite cells, Schwann cells, and vascular endothelial cells of the dorsal root ganglia. The lysosomal lamellated bodies, which were not induced by almitrine, were produced also in cultured rat macrophages exposed to over 1 x 10(-5) M DTMA.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7495377     DOI： 10.1007/s002040050189

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  34 in total

1.  THE PATHOLOGY OF CHLOROQUINE RETINOPATHY.

Authors:  H N BERNSTEIN; J GINSBERG
Journal:  Arch Ophthalmol       Date:  1964-02

Review 2.  A review of the biology and toxicologic implications of the induction of lysosomal lamellar bodies by drugs.

Authors:  M J Reasor
Journal:  Toxicol Appl Pharmacol       Date:  1989-01       Impact factor: 4.219

3.  Polyneuropathy after perhexiline maleate therapy.

Authors:  F Lhermitte; M Fardeau; F Chedru; J Mallecourt
Journal:  Br Med J       Date:  1976-05-22

4.  Lysosomal alterations in cultured macrophages exposed to anorexigenic and psychotropic drugs.

Authors:  D Drenckhahn; L Kleine; R Lüllmann-Rauch
Journal:  Lab Invest       Date:  1976-08       Impact factor: 5.662

Review 5.  Lipidosis induced by amphiphilic cationic drugs.

Authors:  H Lüllmann; R Lüllmann-Rauch; O Wassermann
Journal:  Biochem Pharmacol       Date:  1978       Impact factor: 5.858

6.  Muscle and nerve changes induced by perhexiline maleate in man and mice.

Authors:  M Fardeau; F M Tomé; P Simon
Journal:  Muscle Nerve       Date:  1979 Jan-Feb       Impact factor: 3.217

7.  Almitrine neuropathy. A nerve biopsy study of 8 cases.

Authors:  R Gherardi; M Baudrimont; F Gray; F Louarn
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

8.  Peripheral neuropathies during treatment with almitrine: report of 46 cases.

Authors:  P Bouche; L Lacomblez; J M Leger; M P Chaunu; H Ratinahirana; P Brunet; J J Hauw; H P Cathala; D Laplane
Journal:  J Neurol       Date:  1989-01       Impact factor: 4.849

9.  Experimental phospholipidosis induced by 4,4'-diethyl-aminoethoxyhexestrol. Morphological and biochemical interpretations.

Authors:  Y Tashiro; Y Watanabe; Y Enomoto
Journal:  Acta Pathol Jpn       Date:  1983-09

10.  Lipidosis-like alterations in cultured macrophages exposed to local anaesthetics.

Authors:  M Jägel; R Lüllmann-Rauch
Journal:  Arch Toxicol       Date:  1984-10       Impact factor: 5.153
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.