Literature DB >> 20570125

Quality and quantity control at the endoplasmic reticulum.

Ramanujan S Hegde1, Hidde L Ploegh.   

Abstract

The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins that together make up about one third of the cellular proteome. Cells carefully control the synthetic output of this organelle to regulate both quality and quantity of proteins that emerge. Here, we synthesize current concepts underlying the pathways that mediate protein degradation from the ER and their deployment under physiologic and pathologic conditions. Published by Elsevier Ltd.

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Year:  2010        PMID： 20570125      PMCID： PMC2929805          DOI： 10.1016/j.ceb.2010.05.005

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  78 in total

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  71 in total

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