Literature DB >> 16529947

Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase.

Yihong Ye1.   

Abstract

Cdc48/p97, a member of the AAA (ATPase associated with various cellular activities) ATPase family, participates in various cellular pathways including membrane fusion, protein folding/unfolding, proteolysis-dependent transcriptional control, protein degradation, and spindle disassembly. How Cdc48/p97 can perform such diverse functions is unclear, but the recently established connection between components of the ubiquitination system and various p97 activities suggests that these seemingly unrelated processes mediated by Cdc48/p97 may all be governed by ubiquitin.

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Year:  2006        PMID: 16529947     DOI: 10.1016/j.jsb.2006.01.005

Source DB:  PubMed          Journal:  J Struct Biol        ISSN: 1047-8477            Impact factor:   2.867


  109 in total

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