OBJECTIVES: Among bipolar disorder (BPD) patients, functional recovery, defined as regaining individual premorbid residential and vocational status, is far less common than symptomatic recovery. As several factors have tentatively been implicated in outcomes in BPD, we investigated predictors of functional recovery among BPD patients, including demographic, clinical, and neurocognitive factors. METHODS: We assessed functional recovery status with standardized residential and occupational indices, assessed neurocognitive functioning with performance-based neuropsychological tests, and collected demographic and clinical information for 65 euthymic or residually depressed Structured Clinical Interview for DSM-IV-defined type I or II BPD patients. We examined predictors of functional recovery with multiple logistic regression modeling. RESULTS: More education (p = 0.006), fewer years of illness (p = 0.037), and being married (p = 0.045) were associated independently with functional recovery, even after controlling for residual depressive symptoms, diagnostic type (I versus II), and psychiatric comorbidity. Functionally unrecovered BPD patients performed less well than recovered patients on verbal fluency (effect size = 0.54, p = 0.03), a measure of executive functioning, but this difference was not significant when adjusted for residual mood symptoms and education. CONCLUSIONS: Among euthymic or mildly depressed BPD patients, functional recovery was associated with more education, being married, and fewer years of illness.
OBJECTIVES: Among bipolar disorder (BPD) patients, functional recovery, defined as regaining individual premorbid residential and vocational status, is far less common than symptomatic recovery. As several factors have tentatively been implicated in outcomes in BPD, we investigated predictors of functional recovery among BPD patients, including demographic, clinical, and neurocognitive factors. METHODS: We assessed functional recovery status with standardized residential and occupational indices, assessed neurocognitive functioning with performance-based neuropsychological tests, and collected demographic and clinical information for 65 euthymic or residually depressed Structured Clinical Interview for DSM-IV-defined type I or II BPDpatients. We examined predictors of functional recovery with multiple logistic regression modeling. RESULTS: More education (p = 0.006), fewer years of illness (p = 0.037), and being married (p = 0.045) were associated independently with functional recovery, even after controlling for residual depressive symptoms, diagnostic type (I versus II), and psychiatric comorbidity. Functionally unrecovered BPD patients performed less well than recovered patients on verbal fluency (effect size = 0.54, p = 0.03), a measure of executive functioning, but this difference was not significant when adjusted for residual mood symptoms and education. CONCLUSIONS: Among euthymic or mildly depressed BPDpatients, functional recovery was associated with more education, being married, and fewer years of illness.
Authors: Mauricio Tohen; Carlos A Zarate; John Hennen; Hari-Mandir Kaur Khalsa; Stephen M Strakowski; Priscilla Gebre-Medhin; Paola Salvatore; Ross J Baldessarini Journal: Am J Psychiatry Date: 2003-12 Impact factor: 18.112
Authors: Outi Mantere; Kirsi Suominen; Hanna M Valtonen; Petri Arvilommi; Sami Leppämäki; Tarja Melartin; Erkki Isometsä Journal: Bipolar Disord Date: 2008-05 Impact factor: 6.744
Authors: Robert M Post; Kirk D Denicoff; Gabriele S Leverich; Lori L Altshuler; Mark A Frye; Trisha M Suppes; A John Rush; Paul E Keck; Susan L McElroy; David A Luckenbaugh; Chad Pollio; Ralph Kupka; Willem A Nolen Journal: J Clin Psychiatry Date: 2003-06 Impact factor: 4.384
Authors: Ariel Gildengers; Curtis Tatsuoka; Christopher Bialko; Kristin A Cassidy; Philipp Dines; James Emanuel; Rayan K Al Jurdi; Laszlo Gyulai; Benoit H Mulsant; Robert C Young; Martha Sajatovic Journal: Cut Edge Psychiatry Pract Date: 2013
Authors: Colin A Depp; Brent T Mausbach; Christopher Bowie; Paula Wolyniec; Mary H Thornquist; James R Luke; John A McGrath; Ann E Pulver; Philip D Harvey; Thomas L Patterson Journal: J Affect Disord Date: 2011-11-29 Impact factor: 4.839
Authors: Carrie E Bearden; Vivian H Shih; Michael F Green; Michael Gitlin; Kenneth N Sokolski; Eric Levander; Susan Marusak; Constance Hammen; Catherine A Sugar; Lori L Altshuler Journal: Bipolar Disord Date: 2011-06 Impact factor: 6.744
Authors: Colin A Depp; Brent T Mausbach; Alexandrea L Harmell; Gauri N Savla; Christopher R Bowie; Philip D Harvey; Thomas L Patterson Journal: Bipolar Disord Date: 2012-05 Impact factor: 6.744
Authors: C M Bonnín; C Torrent; J M Goikolea; M Reinares; B Solé; M Valentí; J Sánchez-Moreno; D Hidalgo; R Tabarés-Seisdedos; A Martínez-Arán; E Vieta Journal: Eur Arch Psychiatry Clin Neurosci Date: 2013-08-03 Impact factor: 5.270
Authors: Ralph Kupka; Anne Duffy; Jan Scott; Jorge Almeida; Vicent Balanzá-Martínez; Boris Birmaher; David J Bond; Elisa Brietzke; Ines Chendo; Benicio N Frey; Iria Grande; Danella Hafeman; Tomas Hajek; Manon Hillegers; Marcia Kauer-Sant'Anna; Rodrigo B Mansur; Afra van der Markt; Robert Post; Mauricio Tohen; Hailey Tremain; Gustavo Vazquez; Eduard Vieta; Lakshmi N Yatham; Michael Berk; Martin Alda; Flávio Kapczinski Journal: Bipolar Disord Date: 2021-07-23 Impact factor: 5.345