Literature DB >> 20564573

New biological functions and applications of high-molecular-mass poly-gamma-glutamic acid.

Haryoung Poo1, Chung Park, Mi-Sun Kwak, Doo-Yeol Choi, Seung-Pyo Hong, Il-Han Lee, Yong Taik Lim, Young Ki Choi, Sun-Ryang Bae, Hiroshi Uyama, Chul-Joong Kim, Moon-Hee Sung.   

Abstract

Ultra-high-molecular-weight poly-gamma-glutamic acid (gamma-PGA) is a most promising biodegradable polymer that is produced by Bacillus subtilis (chungkookjang). Attractive properties of gamma-PGA are that it is water soluble, anionic, biodegradable, and edible. Development of gamma-PGA has pursued in terms of cosmetics/skin care, bone care, nanoparticle for drug delivery system, hydrogel, and so on. Very recently, our research has shown that gamma-PGA can be used as an immune-stimulating agent, especially at high molecular weight. This review presents the synthesis and production of high-molecular-weight gamma-PGA and its various applications in industrial fields.

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Year:  2010        PMID： 20564573     DOI： 10.1002/cbdv.200900283

Source DB:  PubMed          Journal:  Chem Biodivers        ISSN： 1612-1872            Impact factor:   2.408


  11 in total

1.  Biocompatible nanopolymers: the next generation of breast cancer treatment?

Authors:  Julia Y Ljubimova; Eggehard Holler
Journal:  Nanomedicine (Lond)       Date:  2012-10       Impact factor: 5.307

Review 2.  Genetic and metabolic engineering for poly-γ-glutamic acid production: current progress, challenges, and prospects.

Authors:  Zheng Zhang; Penghui He; Dongbo Cai; Shouwen Chen
Journal:  World J Microbiol Biotechnol       Date:  2022-08-28       Impact factor: 4.253

3.  Poly-γ-glutamic acid enhances the quality of recombant erythropoietin produced by CHO cells.

Authors:  Tae Gon Kim; Young Chol Cho; Bok-Hwan Chun; Sung Hyo Park; Hoi-Seon Lee; Namhyun Chung
Journal:  Biotechnol Biotechnol Equip       Date:  2014-03-04       Impact factor: 1.632

4.  The Antiviral Effect of High-Molecular Weight Poly-Gamma-Glutamate against Newcastle Disease Virus on Murine Macrophage Cells.

Authors:  Melbourne Talactac; Jong-Soo Lee; Hojin Moon; Mohammed Y E Chowdhury; Chul Joong Kim
Journal:  Adv Virol       Date:  2014-12-30

5.  Poly-γ-Glutamic Acids Contribute to Biofilm Formation and Plant Root Colonization in Selected Environmental Isolates of Bacillus subtilis.

Authors:  Yiyang Yu; Fang Yan; Yun Chen; Christopher Jin; Jian-Hua Guo; Yunrong Chai
Journal:  Front Microbiol       Date:  2016-11-10       Impact factor: 5.640

6.  Poly-γ-glutamic acid/chitosan nanogel greatly enhances the efficacy and heterosubtypic cross-reactivity of H1N1 pandemic influenza vaccine.

Authors:  Jihyun Yang; Sang-Mu Shim; Thi Quyen Nguyen; Eun-Ha Kim; Kwang Kim; Yong Taik Lim; Moon-Hee Sung; Richard Webby; Haryoung Poo
Journal:  Sci Rep       Date:  2017-03-21       Impact factor: 4.379

Review 7.  Chitosan-Based Nanoparticles Against Viral Infections.

Authors:  Homa Boroumand; Fereshteh Badie; Samaneh Mazaheri; Zeynab Sadat Seyedi; Javid Sadri Nahand; Majid Nejati; Hossein Bannazadeh Baghi; Mohammad Abbasi-Kolli; Bita Badehnoosh; Maryam Ghandali; Michael R Hamblin; Hamed Mirzaei
Journal:  Front Cell Infect Microbiol       Date:  2021-03-17       Impact factor: 5.293

Review 8.  From Residues to Added-Value Bacterial Biopolymers as Nanomaterials for Biomedical Applications.

Authors:  Francisco G Blanco; Natalia Hernández; Virginia Rivero-Buceta; Beatriz Maestro; Jesús M Sanz; Aránzazu Mato; Ana M Hernández-Arriaga; M Auxiliadora Prieto
Journal:  Nanomaterials (Basel)       Date:  2021-06-04       Impact factor: 5.076

9.  iNKT Cells Are Responsible for the Apoptotic Reduction of Basophils That Mediate Th2 Immune Responses Elicited by Papain in Mice Following γPGA Stimulation.

Authors:  Hyun Jung Park; Sung Won Lee; Se-Ho Park; Seokmann Hong
Journal:  PLoS One       Date:  2016-04-06       Impact factor: 3.240

Review 10.  The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins.

Authors:  Vladimir N Uversky
Journal:  Intrinsically Disord Proteins       Date:  2013-04-01
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