Literature DB >> 20563537

FHIT: doubts are clear now.

Anjilna Wali1.   

Abstract

The fragile histidine triad (FHIT) gene is a bonafide tumor-suppressor gene present on the short arm of chromosome 3 and its loss of function has been evaluated in different types of cancers. Loss of heterozygosity at various sections of the FHIT gene and the methylation analysis of the promoter region showed that it is one of the important and preliminary genetic alterations in the cell, and its restoration in the cell line or nude mice suppresses tumorigenicity. Current research on the FHIT gene has depicted that Fhit interacts with different proteins through different pathways in the nucleus, mitochondria, and cytoplasm, directing the cell to apoptosis.

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Year:  2010        PMID： 20563537      PMCID： PMC5763754          DOI： 10.1100/tsw.2010.110

Source DB:  PubMed          Journal:  ScientificWorldJournal        ISSN： 1537-744X


  14 in total

1.  Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer.

Authors:  Rabeah Abbas Al-Temaimi; Sindhu Jacob; Waleed Al-Ali; Diana Ann Thomas; Fahd Al-Mulla
Journal:  J Histochem Cytochem       Date:  2013-06-24       Impact factor: 2.479

2.  The effect of adenovirus-mediated gene expression of FHIT in small cell lung cancer cells.

Authors:  Roza Zandi; Kai Xu; Hans S Poulsen; Jack A Roth; Lin Ji
Journal:  Cancer Invest       Date:  2011-12       Impact factor: 2.176

3.  Comparison of structural genetics of non-schistosoma-associated squamous cell carcinoma of the urinary bladder.

Authors:  Marina Molitor; Kerstin Junker; Elke Eltze; Marieta Toma; Stefan Denzinger; Sabine Siegert; Ruth Knuechel; Nadine T Gaisa
Journal:  Int J Clin Exp Pathol       Date:  2015-07-01

4.  An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.

Authors:  Nese Direk; Stephanie Williams; Jennifer A Smith; Stephan Ripke; Tracy Air; Azmeraw T Amare; Najaf Amin; Bernhard T Baune; David A Bennett; Douglas H R Blackwood; Dorret Boomsma; Gerome Breen; Henriette N Buttenschøn; Enda M Byrne; Anders D Børglum; Enrique Castelao; Sven Cichon; Toni-Kim Clarke; Marilyn C Cornelis; Udo Dannlowski; Philip L De Jager; Ayse Demirkan; Enrico Domenici; Cornelia M van Duijn; Erin C Dunn; Johan G Eriksson; Tonu Esko; Jessica D Faul; Luigi Ferrucci; Myriam Fornage; Eco de Geus; Michael Gill; Scott D Gordon; Hans Jörgen Grabe; Gerard van Grootheest; Steven P Hamilton; Catharina A Hartman; Andrew C Heath; Karin Hek; Albert Hofman; Georg Homuth; Carsten Horn; Jouke Jan Hottenga; Sharon L R Kardia; Stefan Kloiber; Karestan Koenen; Zoltán Kutalik; Karl-Heinz Ladwig; Jari Lahti; Douglas F Levinson; Cathryn M Lewis; Glyn Lewis; Qingqin S Li; David J Llewellyn; Susanne Lucae; Kathryn L Lunetta; Donald J MacIntyre; Pamela Madden; Nicholas G Martin; Andrew M McIntosh; Andres Metspalu; Yuri Milaneschi; Grant W Montgomery; Ole Mors; Thomas H Mosley; Joanne M Murabito; Bertram Müller-Myhsok; Markus M Nöthen; Dale R Nyholt; Michael C O'Donovan; Brenda W Penninx; Michele L Pergadia; Roy Perlis; James B Potash; Martin Preisig; Shaun M Purcell; Jorge A Quiroz; Katri Räikkönen; John P Rice; Marcella Rietschel; Margarita Rivera; Thomas G Schulze; Jianxin Shi; Stanley Shyn; Grant C Sinnamon; Johannes H Smit; Jordan W Smoller; Harold Snieder; Toshiko Tanaka; Katherine E Tansey; Alexander Teumer; Rudolf Uher; Daniel Umbricht; Sandra Van der Auwera; Erin B Ware; David R Weir; Myrna M Weissman; Gonneke Willemsen; Jingyun Yang; Wei Zhao; Henning Tiemeier; Patrick F Sullivan
Journal:  Biol Psychiatry       Date:  2016-12-08       Impact factor: 13.382

5.  Multiple Patterns of FHIT Gene Homozygous Deletion in Egyptian Breast Cancer Patients.

Authors:  Heba M S Ismail; Amina M Medhat; Amr M Karim; Nadia I Zakhary
Journal:  Int J Breast Cancer       Date:  2011-10-19

Review 6.  The clinicopathological significance of FHIT hypermethylation in non-small cell lung cancer, a meta-analysis and literature review.

Authors:  Wei Yan; Ning Xu; Xiang Han; Xiao-Ming Zhou; Bei He
Journal:  Sci Rep       Date:  2016-01-22       Impact factor: 4.379

7.  Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation.

Authors:  L E Moore; E Jaeger; M L Nickerson; P Brennan; S De Vries; R Roy; J Toro; H Li; S Karami; P Lenz; D Zaridze; V Janout; V Bencko; M Navratilova; N Szeszenia-Dabrowska; D Mates; W M Linehan; M Merino; J Simko; R Pfeiffer; P Boffetta; S Hewitt; N Rothman; W-H Chow; F M Waldman
Journal:  Oncogenesis       Date:  2012-06-25       Impact factor: 7.485

8.  FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension.

Authors:  Svenja Dannewitz Prosseda; Xuefei Tian; Kazuya Kuramoto; Mario Boehm; Deepti Sudheendra; Kazuya Miyagawa; Fan Zhang; David Solow-Cordero; Joshua C Saldivar; Eric D Austin; James E Loyd; Lisa Wheeler; Adam Andruska; Michele Donato; Lingli Wang; Kay Huebner; Ross J Metzger; Purvesh Khatri; Edda Spiekerkoetter
Journal:  Am J Respir Crit Care Med       Date:  2019-01-01       Impact factor: 30.528

Review 9.  The clinicopathological significance and drug target potential of FHIT in breast cancer, a meta-analysis and literature review.

Authors:  Yunshu Su; Xiaoli Wang; Jun Li; Junming Xu; Lijun Xu
Journal:  Drug Des Devel Ther       Date:  2015-10-01       Impact factor: 4.162

10.  Promoter methylation of tumor suppressor genes in pre-neoplastic lesions; potential marker of disease recurrence.

Authors:  Claudia Rengucci; Giulia De Maio; Andrea Casadei Gardini; Mattia Zucca; Emanuela Scarpi; Chiara Zingaretti; Giovanni Foschi; Maria Maddalena Tumedei; Chiara Molinari; Luca Saragoni; Maurizio Puccetti; Dino Amadori; Wainer Zoli; Daniele Calistri
Journal:  J Exp Clin Cancer Res       Date:  2014-08-05
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