PURPOSE: To improve a questionnaire used to collect patient-reported outcomes from patients with early stage prostate cancer treated with brachytherapy. A secondary aim was to adapt the Late Effects of Normal Tissue (LENT) subjective toxicity questionnaire for use to collect Common Terminology Criteria for Adverse Events (CTCAE) data, the current preferred platform for assessing radiation toxicity. MATERIALS AND METHODS: Three hundred and seventy-seven patients were treated with permanent iodine-125 seed implant brachytherapy for early prostate cancer. Toxicity data were collected before and at nine time points post-treatment (0-36 months). Compliance rates for patients completing individual items and item-subsection correlation coefficients were calculated. A factor analysis was carried out to analyse responses to the questionnaire and identify less informative questions, which could be removed. Cronbach's α coefficient was used to measure reliability. RESULTS: Two thousand one hundred and eighty-eight questionnaires were analysed. There was poor compliance for questions specifically relating to operations and bowel medication. We found that the division of the questionnaire into subsections based on anatomical site was reasonable and that certain items could be safely removed. The high mean value for Cronbach's α across all questionnaires (0.752; 95% CI: 0.726-0.779) indicated that the questionnaire was reliable. Fifteen of the 44 questions were removed from the original questionnaires. Questions on urinary incontinence severity, management of urinary and bowel incontinence, effects of reduced flow of urine and the effects of symptoms on activity of daily living and change in sexual function were required to adapt the LENT subjective questionnaire for use to collect CTCAE data. CONCLUSIONS: A questionnaire, validated over 6 years to collect LENT subjective data were adapted and is a reliable approach for collecting CTCAE data after prostate brachytherapy.
PURPOSE: To improve a questionnaire used to collect patient-reported outcomes from patients with early stage prostate cancer treated with brachytherapy. A secondary aim was to adapt the Late Effects of Normal Tissue (LENT) subjective toxicity questionnaire for use to collect Common Terminology Criteria for Adverse Events (CTCAE) data, the current preferred platform for assessing radiation toxicity. MATERIALS AND METHODS: Three hundred and seventy-seven patients were treated with permanent iodine-125 seed implant brachytherapy for early prostate cancer. Toxicity data were collected before and at nine time points post-treatment (0-36 months). Compliance rates for patients completing individual items and item-subsection correlation coefficients were calculated. A factor analysis was carried out to analyse responses to the questionnaire and identify less informative questions, which could be removed. Cronbach's α coefficient was used to measure reliability. RESULTS: Two thousand one hundred and eighty-eight questionnaires were analysed. There was poor compliance for questions specifically relating to operations and bowel medication. We found that the division of the questionnaire into subsections based on anatomical site was reasonable and that certain items could be safely removed. The high mean value for Cronbach's α across all questionnaires (0.752; 95% CI: 0.726-0.779) indicated that the questionnaire was reliable. Fifteen of the 44 questions were removed from the original questionnaires. Questions on urinary incontinence severity, management of urinary and bowel incontinence, effects of reduced flow of urine and the effects of symptoms on activity of daily living and change in sexual function were required to adapt the LENT subjective questionnaire for use to collect CTCAE data. CONCLUSIONS: A questionnaire, validated over 6 years to collect LENT subjective data were adapted and is a reliable approach for collecting CTCAE data after prostate brachytherapy.
Authors: Maria Thor; Caroline E Olsson; Jung Hun Oh; David Alsadius; Niclas Pettersson; Joseph O Deasy; Gunnar Steineck Journal: J Sex Med Date: 2015-11-13 Impact factor: 3.802
Authors: Jung Hun Oh; Maria Thor; Caroline Olsson; Viktor Skokic; Rebecka Jörnsten; David Alsadius; Niclas Pettersson; Gunnar Steineck; Joseph O Deasy Journal: Methods Inf Med Date: 2016-09-02 Impact factor: 2.176
Authors: M Thor; C E Olsson; J H Oh; J Hedström; N Pauli; M Johansson; J O Deasy; C Finizia Journal: Clin Otolaryngol Date: 2017-05-29 Impact factor: 2.597
Authors: Jennifer L Hay; Thomas M Atkinson; Bryce B Reeve; Sandra A Mitchell; Tito R Mendoza; Gordon Willis; Lori M Minasian; Steven B Clauser; Andrea Denicoff; Ann O'Mara; Alice Chen; Antonia V Bennett; Diane B Paul; Joshua Gagne; Lauren Rogak; Laura Sit; Vish Viswanath; Deborah Schrag; Ethan Basch Journal: Qual Life Res Date: 2013-07-20 Impact factor: 4.147
Authors: Ronald C Chen; Peter Chang; Richard J Vetter; Himansu Lukka; William A Stokes; Martin G Sanda; Deborah Watkins-Bruner; Bryce B Reeve; Howard M Sandler Journal: J Natl Cancer Inst Date: 2014-07-08 Impact factor: 13.506
Authors: D J J Farnell; J Staffurth; S Sivell; S Ahmedzai; J Andreyev; J Green; D S Sanders; C J Ferguson; S Pickett; A Muls; R O'Shea; S H Campbell; S E Taylor; A Nelson Journal: Clin Transl Radiat Oncol Date: 2020-02-04
Authors: Patricia Holch; Simon Pini; Ann M Henry; Susan Davidson; Jacki Routledge; Julia Brown; Kate Absolom; Alexandra Gilbert; Kevin Franks; Claire Hulme; Carolyn Morris; Galina Velikova Journal: Pilot Feasibility Stud Date: 2018-06-05
Authors: Michela Carlotta Massi; Francesca Gasperoni; Francesca Ieva; Anna Maria Paganoni; Paolo Zunino; Andrea Manzoni; Nicola Rares Franco; Liv Veldeman; Piet Ost; Valérie Fonteyne; Christopher J Talbot; Tim Rattay; Adam Webb; Paul R Symonds; Kerstie Johnson; Maarten Lambrecht; Karin Haustermans; Gert De Meerleer; Dirk de Ruysscher; Ben Vanneste; Evert Van Limbergen; Ananya Choudhury; Rebecca M Elliott; Elena Sperk; Carsten Herskind; Marlon R Veldwijk; Barbara Avuzzi; Tommaso Giandini; Riccardo Valdagni; Alessandro Cicchetti; David Azria; Marie-Pierre Farcy Jacquet; Barry S Rosenstein; Richard G Stock; Kayla Collado; Ana Vega; Miguel Elías Aguado-Barrera; Patricia Calvo; Alison M Dunning; Laura Fachal; Sarah L Kerns; Debbie Payne; Jenny Chang-Claude; Petra Seibold; Catharine M L West; Tiziana Rancati Journal: Front Oncol Date: 2020-10-15 Impact factor: 6.244