Literature DB >> 20560675

Innovative diagnostic technologies and their significance for personalized medicine.

Kewal K Jain1.   

Abstract

Molecular diagnostics plays an important role in the development of personalized medicine. Innovative diagnostic technologies that are increasingly utilized in personalizing treatment include novel polymerase chain reaction (PCR), direct molecular analysis without amplification, DNA sequencing, biochips/microarrays, and nanobiotechnologies. Technologies for detection of copy number variations, single nucleotide polymorphisms, and cytogenetic alterations provide basic information for personalized medicine. Molecular diagnostic technologies are used for the detection of biomarkers, which may form the common basis of diagnostics and therapeutics. Finally, integration of diagnostics with therapeutics is an important component of personalized medicine.

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Year:  2010        PMID： 20560675     DOI： 10.1007/bf03256366

Source DB:  PubMed          Journal:  Mol Diagn Ther        ISSN： 1177-1062            Impact factor:   4.074


  12 in total

1.  Interpretation of association signals and identification of causal variants from genome-wide association studies.

Authors:  Kai Wang; Samuel P Dickson; Catherine A Stolle; Ian D Krantz; David B Goldstein; Hakon Hakonarson
Journal:  Am J Hum Genet       Date:  2010-04-29       Impact factor: 11.025

Review 2.  SNP genotyping: technologies and biomedical applications.

Authors:  Sobin Kim; Ashish Misra
Journal:  Annu Rev Biomed Eng       Date:  2007       Impact factor: 9.590

Review 3.  Personalized clinical laboratory diagnostics.

Authors:  Kewal K Jain
Journal:  Adv Clin Chem       Date:  2009       Impact factor: 5.394

4.  Single-molecule genomics.

Authors:  Frank McCaughan; Paul H Dear
Journal:  J Pathol       Date:  2010-01       Impact factor: 7.996

5.  Copy number variations in the human genome and strategies for analysis.

Authors:  Emily A Vucic; Kelsie L Thu; Ariane C Williams; Wan L Lam; Bradley P Coe
Journal:  Methods Mol Biol       Date:  2010

6.  Global variation in copy number in the human genome.

Authors:  Richard Redon; Shumpei Ishikawa; Karen R Fitch; Lars Feuk; George H Perry; T Daniel Andrews; Heike Fiegler; Michael H Shapero; Andrew R Carson; Wenwei Chen; Eun Kyung Cho; Stephanie Dallaire; Jennifer L Freeman; Juan R González; Mònica Gratacòs; Jing Huang; Dimitrios Kalaitzopoulos; Daisuke Komura; Jeffrey R MacDonald; Christian R Marshall; Rui Mei; Lyndal Montgomery; Kunihiro Nishimura; Kohji Okamura; Fan Shen; Martin J Somerville; Joelle Tchinda; Armand Valsesia; Cara Woodwark; Fengtang Yang; Junjun Zhang; Tatiana Zerjal; Jane Zhang; Lluis Armengol; Donald F Conrad; Xavier Estivill; Chris Tyler-Smith; Nigel P Carter; Hiroyuki Aburatani; Charles Lee; Keith W Jones; Stephen W Scherer; Matthew E Hurles
Journal:  Nature       Date:  2006-11-23       Impact factor: 49.962

Review 7.  Genomic copy number variation, human health, and disease.

Authors:  Louise V Wain; John A L Armour; Martin D Tobin
Journal:  Lancet       Date:  2009-06-15       Impact factor: 79.321

8.  Paired-end mapping reveals extensive structural variation in the human genome.

Authors:  Jan O Korbel; Alexander Eckehart Urban; Jason P Affourtit; Brian Godwin; Fabian Grubert; Jan Fredrik Simons; Philip M Kim; Dean Palejev; Nicholas J Carriero; Lei Du; Bruce E Taillon; Zhoutao Chen; Andrea Tanzer; A C Eugenia Saunders; Jianxiang Chi; Fengtang Yang; Nigel P Carter; Matthew E Hurles; Sherman M Weissman; Timothy T Harkins; Mark B Gerstein; Michael Egholm; Michael Snyder
Journal:  Science       Date:  2007-09-27       Impact factor: 47.728

Review 9.  Cancer biomarkers: current issues and future directions.

Authors:  Kewal K Jain
Journal:  Curr Opin Mol Ther       Date:  2007-12

10.  Mapping and sequencing of structural variation from eight human genomes.

Authors:  Jeffrey M Kidd; Gregory M Cooper; William F Donahue; Hillary S Hayden; Nick Sampas; Tina Graves; Nancy Hansen; Brian Teague; Can Alkan; Francesca Antonacci; Eric Haugen; Troy Zerr; N Alice Yamada; Peter Tsang; Tera L Newman; Eray Tüzün; Ze Cheng; Heather M Ebling; Nadeem Tusneem; Robert David; Will Gillett; Karen A Phelps; Molly Weaver; David Saranga; Adrianne Brand; Wei Tao; Erik Gustafson; Kevin McKernan; Lin Chen; Maika Malig; Joshua D Smith; Joshua M Korn; Steven A McCarroll; David A Altshuler; Daniel A Peiffer; Michael Dorschner; John Stamatoyannopoulos; David Schwartz; Deborah A Nickerson; James C Mullikin; Richard K Wilson; Laurakay Bruhn; Maynard V Olson; Rajinder Kaul; Douglas R Smith; Evan E Eichler
Journal:  Nature       Date:  2008-05-01       Impact factor: 49.962
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  3 in total

Review 1.  New steps for treating alcohol use disorder.

Authors:  Erin J Campbell; Andrew J Lawrence; Christina J Perry
Journal:  Psychopharmacology (Berl)       Date:  2018-03-25       Impact factor: 4.530

2.  Development of CYP21A2 Genotyping Assay for the Diagnosis of Congenital Adrenal Hyperplasia.

Authors:  Mayara Jorgens Prado; Simone Martins de Castro; Cristiane Kopacek; Maricilda Palandi de Mello; Thaiane Rispoli; Tarciana Grandi; Cláudia Maria Dornelles da Silva; Maria Lucia Rosa Rossetti
Journal:  Mol Diagn Ther       Date:  2017-12       Impact factor: 4.074

Review 3.  Smart Nanoparticles for Chemo-Based Combinational Therapy.

Authors:  Binita Shrestha; Lijun Wang; Eric M Brey; Gabriela Romero Uribe; Liang Tang
Journal:  Pharmaceutics       Date:  2021-06-08       Impact factor: 6.525
  3 in total

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