Literature DB >> 20560035

Stem cells in the infarcted heart.

Dinender K Singla1.   

Abstract

Stem cell transplantation is currently generating a significant interest for use in the future treatment of cardiovascular diseases. Stem cell populations are rapidly increasing, and we are still in the search of optimal cell types to use in clinical trials as bone marrow stem cells did not show significant improvement in cardiac function following transplantation. Experimental stem cell studies raised the question on the true differentiation of tissue-specific cell types following transplantation. In fact, recent studies suggest that improved cardiac function is associated with inhibition of apoptosis and fibrosis provided by factors released from stem cells following transplantation. In this review, we will discuss the effects of transplanted stem cells on engraftment and differentiation as well as factors released from stem cells on apoptosis and cardiac remodeling.

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Year:  2009        PMID： 20560035     DOI： 10.1007/s12265-009-9151-4

Source DB:  PubMed          Journal:  J Cardiovasc Transl Res        ISSN： 1937-5387            Impact factor:   4.132


  49 in total

1.  Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats.

Authors:  Jiang-Yong Min; Yinke Yang; Kimber L Converso; Lixin Liu; Qin Huang; James P Morgan; Yong-Fu Xiao
Journal:  J Appl Physiol (1985)       Date:  2002-01

2.  Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.

Authors:  Massimiliano Gnecchi; Huamei He; Olin D Liang; Luis G Melo; Fulvio Morello; Hui Mu; Nicolas Noiseux; Lunan Zhang; Richard E Pratt; Joanne S Ingwall; Victor J Dzau
Journal:  Nat Med       Date:  2005-04       Impact factor: 53.440

3.  Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial.

Authors:  Gerd P Meyer; Kai C Wollert; Joachim Lotz; Jan Steffens; Peter Lippolt; Stephanie Fichtner; Hartmut Hecker; Arnd Schaefer; Lubomir Arseniev; Bernd Hertenstein; Arnold Ganser; Helmut Drexler
Journal:  Circulation       Date:  2006-03-06       Impact factor: 29.690

4.  Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells.

Authors:  Timothy J Nelson; Almudena Martinez-Fernandez; Satsuki Yamada; Carmen Perez-Terzic; Yasuhiro Ikeda; Andre Terzic
Journal:  Circulation       Date:  2009-07-20       Impact factor: 29.690

5.  Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.

Authors:  Volker Schächinger; Sandra Erbs; Albrecht Elsässer; Werner Haberbosch; Rainer Hambrecht; Hans Hölschermann; Jiangtao Yu; Roberto Corti; Detlef G Mathey; Christian W Hamm; Tim Süselbeck; Birgit Assmus; Torsten Tonn; Stefanie Dimmeler; Andreas M Zeiher
Journal:  N Engl J Med       Date:  2006-09-21       Impact factor: 91.245

6.  Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types.

Authors:  Dinender K Singla; Timothy A Hacker; Lining Ma; Pamela S Douglas; Ruth Sullivan; Gary E Lyons; Timothy J Kamp
Journal:  J Mol Cell Cardiol       Date:  2005-11-08       Impact factor: 5.000

Review 7.  Oxidative stress and apoptosis in heart dysfunction.

Authors:  Dinender Kumar; Huiquan Lou; Pawan K Singal
Journal:  Herz       Date:  2002-11       Impact factor: 1.443

8.  Stem cell differentiation requires a paracrine pathway in the heart.

Authors:  Atta Behfar; Leonid V Zingman; Denice M Hodgson; Jean-Michel Rauzier; Garvan C Kane; Andre Terzic; Michel Pucéat
Journal:  FASEB J       Date:  2002-10       Impact factor: 5.191

Review 9.  Embryonic stem cells in cardiac repair and regeneration.

Authors:  Dinender K Singla
Journal:  Antioxid Redox Signal       Date:  2009-08       Impact factor: 8.401

10.  Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling.

Authors:  Dinender K Singla; Gary E Lyons; Timothy J Kamp
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-04-06       Impact factor: 4.733
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  7 in total

1.  Activation of diverse signaling pathways by ex-vivo delivery of multiple cytokines for myocardial repair.

Authors:  Mikhail Konoplyannikov; Khawaja Husnain Haider; Vien Khach Lai; Rafeeq P H Ahmed; Shujia Jiang; Muhammad Ashraf
Journal:  Stem Cells Dev       Date:  2012-10-05       Impact factor: 3.272

2.  Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function.

Authors:  Bo Dai; Wei Huang; Meifeng Xu; Ronald W Millard; Mei Hua Gao; H Kirk Hammond; Donald R Menick; Muhammad Ashraf; Yigang Wang
Journal:  J Am Coll Cardiol       Date:  2011-11-08       Impact factor: 24.094

3.  MicroRNA-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the PTEN/Akt pathway in the infarcted heart.

Authors:  Carley Glass; Dinender K Singla
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-08-19       Impact factor: 4.733

4.  Encapsulated glucagon-like peptide-1-producing mesenchymal stem cells have a beneficial effect on failing pig hearts.

Authors:  Elizabeth J Wright; Kelly A Farrell; Nadim Malik; Moustapha Kassem; Andrew L Lewis; Christine Wallrapp; Cathy M Holt
Journal:  Stem Cells Transl Med       Date:  2012-09-27       Impact factor: 6.940

5.  Mesenchymal stem cells: from experiment to clinic.

Authors:  William R Otto; Nicholas A Wright
Journal:  Fibrogenesis Tissue Repair       Date:  2011-09-08

6.  Immortalized porcine mesenchymal cells derived from nasal mucosa, lungs, lymph nodes, spleen and bone marrow retain their stemness properties and trigger the expression of siglec-1 in co-cultured blood monocytic cells.

Authors:  Abubakar Garba; Lowiese M B Desmarets; Delphine D Acar; Bert Devriendt; Hans J Nauwynck
Journal:  PLoS One       Date:  2017-10-16       Impact factor: 3.240

7.  The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium.

Authors:  Tomoyo Sasaki; Hyosook Hwang; Cu Nguyen; Robert A Kloner; Michael Kahn
Journal:  PLoS One       Date:  2013-09-12       Impact factor: 3.240
  7 in total

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