OBJECTIVE: Based on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease. METHODS: Standard association tests were employed, followed by newer multilocus association methods (genotype patterns). RESULTS: Individually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively. CONCLUSIONS: These findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect.
OBJECTIVE: Based on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease. METHODS: Standard association tests were employed, followed by newer multilocus association methods (genotype patterns). RESULTS: Individually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively. CONCLUSIONS: These findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect.
Authors: G Passarino; P A Underhill; L L Cavalli-Sforza; O Semino; G M Pes; C Carru; L Ferrucci; M Bonafè; C Franceschi; L Deiana; G Baggio; G De Benedictis Journal: Hum Hered Date: 2001 Impact factor: 0.444
Authors: S Heath; R Robledo; W Beggs; G Feola; C Parodo; A Rinaldi; L Contu; D Dana; D Stambolian; M Siniscalco Journal: Hum Hered Date: 2001 Impact factor: 0.444
Authors: R H Houwen; S Baharloo; K Blankenship; P Raeymaekers; J Juyn; L A Sandkuijl; N B Freimer Journal: Nat Genet Date: 1994-12 Impact factor: 38.330
Authors: G Vazza; C Bertolin; E Scudellaro; A Vettori; F Boaretto; S Rampinelli; G De Sanctis; G Perini; P Peruzzi; M L Mostacciuolo Journal: Mol Psychiatry Date: 2006-09-12 Impact factor: 15.992
Authors: Tom Walsh; Jon M McClellan; Shane E McCarthy; Anjené M Addington; Sarah B Pierce; Greg M Cooper; Alex S Nord; Mary Kusenda; Dheeraj Malhotra; Abhishek Bhandari; Sunday M Stray; Caitlin F Rippey; Patricia Roccanova; Vlad Makarov; B Lakshmi; Robert L Findling; Linmarie Sikich; Thomas Stromberg; Barry Merriman; Nitin Gogtay; Philip Butler; Kristen Eckstrand; Laila Noory; Peter Gochman; Robert Long; Zugen Chen; Sean Davis; Carl Baker; Evan E Eichler; Paul S Meltzer; Stanley F Nelson; Andrew B Singleton; Ming K Lee; Judith L Rapoport; Mary-Claire King; Jonathan Sebat Journal: Science Date: 2008-03-27 Impact factor: 47.728
Authors: Sven Cichon; Nick Craddock; Mark Daly; Stephen V Faraone; Pablo V Gejman; John Kelsoe; Thomas Lehner; Douglas F Levinson; Audra Moran; Pamela Sklar; Patrick F Sullivan Journal: Am J Psychiatry Date: 2009-04-01 Impact factor: 18.112
Authors: Man K Chan; Jason D Cooper; Stefanie Heilmann-Heimbach; Josef Frank; Stephanie H Witt; Markus M Nöthen; Johann Steiner; Marcella Rietschel; Sabine Bahn Journal: Sci Rep Date: 2017-10-03 Impact factor: 4.379