| Literature DB >> 2055727 |
R H Cohan1, R A Leder, A J Herzberg, L W Hedlund, C T Wheeler, C A Beam, S N Nadel, N R Dunnick.
Abstract
We compared the relative toxicities of standard concentrations of two magnetic resonance imaging (MRI) contrast agents, ionic gadolinium diethylenetriaminepentacetic acid (DTPA) and low-osmolar gadolinium-1, 4, 7 tris (carboxymethyl)-10-(2'-hydroxypropyl)-1, 4, 7, 10 tetra-azacyclododecane (HP-DO3A) with that of the conventional radiographic contrast medium meglumine diatrizoate, when extravasated into the deep dermal tissues of laboratory rats. Gadolinium-DTPA caused moderate necrosis, hemorrhage, and edema which was not statistically different than meglumine diatrizoate. In contrast, gadolinium HP-DO3A was significantly less toxic than meglumine diatrizoate. Additional experience will be needed in order to determine whether these laboratory results will be clinically relevant in humans.Entities:
Mesh：
Substances：
Year: 1991 PMID： 2055727 DOI： 10.1097/00004424-199103000-00005
Source DB: PubMed Journal: Invest Radiol ISSN： 0020-9996 Impact factor: 6.016