Literature DB >> 20555359

Sphingosine 1-phosphate and cancer.

Nigel J Pyne1, Susan Pyne.   

Abstract

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.

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Year:  2010        PMID： 20555359     DOI： 10.1038/nrc2875

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  198 in total

1.  Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

Authors:  Kazuaki Takabe; Roger H Kim; Jeremy C Allegood; Poulami Mitra; Subramaniam Ramachandran; Masayuki Nagahashi; Kuzhuvelil B Harikumar; Nitai C Hait; Sheldon Milstien; Sarah Spiegel
Journal:  J Biol Chem       Date:  2010-01-28       Impact factor: 5.157

2.  Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects.

Authors:  Jennifer R Gamble; Pu Xia; Christopher N Hahn; Jenny J Drew; Christopher J Drogemuller; David Brown; Mathew A Vadas
Journal:  Int J Cancer       Date:  2006-05-15       Impact factor: 7.396

3.  FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.

Authors:  Takanobu Ubai; Haruhito Azuma; Yatsugu Kotake; Teruo Inamoto; Kiyoshi Takahara; Yuko Ito; Satoshi Kiyama; Takeshi Sakamoto; Shigeo Horie; Satoru Muto; Shiro Takahara; Yoshinori Otsuki; Yoji Katsuoka
Journal:  Anticancer Res       Date:  2007 Jan-Feb       Impact factor: 2.480

4.  Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.

Authors:  Victor E Nava; John Peyton Hobson; Shvetha Murthy; Sheldon Milstien; Sarah Spiegel
Journal:  Exp Cell Res       Date:  2002-11-15       Impact factor: 3.905

5.  Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart.

Authors:  Donald A Vessey; Michael Kelley; Jianqing Zhang; Luyi Li; Rong Tao; Joel S Karliner
Journal:  J Biochem Mol Toxicol       Date:  2007       Impact factor: 3.642

6.  Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.

Authors:  Yasuo Nagaoka; Kota Otsuki; Tetsuro Fujita; Shinichi Uesato
Journal:  Biol Pharm Bull       Date:  2008-06       Impact factor: 2.233

7.  Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival.

Authors:  Yuya Yoshida; Mitsutoshi Nakada; Naotoshi Sugimoto; Tomoya Harada; Yasuhiko Hayashi; Daisuke Kita; Naoyuki Uchiyama; Yutaka Hayashi; Akihiro Yachie; Yoh Takuwa; Jun-Ichiro Hamada
Journal:  Int J Cancer       Date:  2010-05-15       Impact factor: 7.396

8.  Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity.

Authors:  Kayo Arikawa; Noriko Takuwa; Hironori Yamaguchi; Naotoshi Sugimoto; Joji Kitayama; Hirokazu Nagawa; Kazuhiko Takehara; Yoh Takuwa
Journal:  J Biol Chem       Date:  2003-06-16       Impact factor: 5.157

Review 9.  Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination.

Authors:  Nigel J Pyne; Susan Pyne
Journal:  Biochim Biophys Acta       Date:  2008-06-17

10.  Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival.

Authors:  Audrey Dayon; Leyre Brizuela; Claire Martin; Catherine Mazerolles; Nelly Pirot; Nicolas Doumerc; Leonor Nogueira; Muriel Golzio; Justin Teissié; Guy Serre; Pascal Rischmann; Bernard Malavaud; Olivier Cuvillier
Journal:  PLoS One       Date:  2009-11-26       Impact factor: 3.240
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  398 in total

1.  Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration.

Authors:  Gianfranco Matrone; Shu Meng; Qilin Gu; Jie Lv; Longhou Fang; Kaifu Chen; John P Cooke
Journal:  Arterioscler Thromb Vasc Biol       Date:  2017-08-03       Impact factor: 8.311

2.  The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.

Authors:  Carolyn Loveridge; Francesca Tonelli; Tamara Leclercq; Keng Gat Lim; Jaclyn S Long; Evgeny Berdyshev; Rothwelle J Tate; Viswanathan Natarajan; Stuart M Pitson; Nigel J Pyne; Susan Pyne
Journal:  J Biol Chem       Date:  2010-10-06       Impact factor: 5.157

3.  Characterization of a sphingosine 1-phosphate receptor antagonist prodrug.

Authors:  Perry C Kennedy; Ran Zhu; Tao Huang; Jose L Tomsig; Thomas P Mathews; Marion David; Olivier Peyruchaud; Timothy L Macdonald; Kevin R Lynch
Journal:  J Pharmacol Exp Ther       Date:  2011-06-01       Impact factor: 4.030

4.  Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.

Authors:  Mithun R Raje; Kenneth Knott; Yugesh Kharel; Philippe Bissel; Kevin R Lynch; Webster L Santos
Journal:  Bioorg Med Chem       Date:  2011-11-15       Impact factor: 3.641

Review 5.  Shaping the landscape: metabolic regulation of S1P gradients.

Authors:  Ana Olivera; Maria Laura Allende; Richard L Proia
Journal:  Biochim Biophys Acta       Date:  2012-06-23

Review 6.  Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.

Authors:  Roger A Sabbadini
Journal:  Br J Pharmacol       Date:  2011-03       Impact factor: 8.739

7.  Enhanced tumor cures after Foscan photodynamic therapy combined with the ceramide analog LCL29. Evidence from mouse squamous cell carcinomas for sphingolipids as biomarkers of treatment response.

Authors:  D Separovic; J Bielawski; J S Pierce; S Merchant; A L Tarca; G Bhatti; B Ogretmen; M Korbelik
Journal:  Int J Oncol       Date:  2010-12-06       Impact factor: 5.650

8.  Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter.

Authors:  Taketoshi Kajimoto; Alisha D Caliman; Irene S Tobias; Taro Okada; Caila A Pilo; An-Angela N Van; J Andrew McCammon; Shun-Ichi Nakamura; Alexandra C Newton
Journal:  Sci Signal       Date:  2019-01-01       Impact factor: 8.192

9.  Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.

Authors:  Hiroaki Aoki; Masayo Aoki; Eriko Katsuta; Rajesh Ramanathan; Michael O Idowu; Sarah Spiegel; Kazuaki Takabe
Journal:  J Surg Res       Date:  2016-07-09       Impact factor: 2.192

Review 10.  Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.

Authors:  Masayuki Nagahashi; Nitai C Hait; Michael Maceyka; Dorit Avni; Kazuaki Takabe; Sheldon Milstien; Sarah Spiegel
Journal:  Adv Biol Regul       Date:  2013-10-16
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