Literature DB >> 20547808

Extended-spectrum cephalosporinase in Acinetobacter baumannii.

José-Manuel Rodríguez-Martínez1, Patrice Nordmann, Esthel Ronco, Laurent Poirel.   

Abstract

An AmpC-type beta-lactamase conferring high-level resistance to expanded-spectrum cephalosporins and monobactams was characterized from an Acinetobacter baumannii clinical isolate. This class C beta-lactamase (named ADC-33) possessed a Pro210Arg substitution together with a duplication of an Ala residue at position 215 (inside the Omega-loop) compared to a reference AmpC cephalosporinase from A. baumannii. ADC-33 hydrolyzed ceftazidime, cefepime, and aztreonam at high levels, which allows the classification of this enzyme as an extended-spectrum AmpC (ESAC). Site-directed mutagenesis confirmed the role of both substitutions in its ESAC property.

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Year:  2010        PMID： 20547808      PMCID： PMC2916328          DOI： 10.1128/AAC.00050-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.

Authors:  Laurent Poirel; Sophie Marqué; Claire Héritier; Christine Segonds; Gérard Chabanon; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

Review 2.  A functional classification scheme for beta-lactamases and its correlation with molecular structure.

Authors:  K Bush; G A Jacoby; A A Medeiros
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

3.  Structure of the extended-spectrum class C beta-lactamase of Enterobacter cloacae GC1, a natural mutant with a tandem tripeptide insertion.

Authors:  G V Crichlow; A P Kuzin; M Nukaga; K Mayama; T Sawai; J R Knox
Journal:  Biochemistry       Date:  1999-08-10       Impact factor: 3.162

4.  Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase, ADC-7 beta-lactamase: defining a unique family of class C enzymes.

Authors:  Kristine M Hujer; Nashaat S Hamza; Andrea M Hujer; Federico Perez; Marion S Helfand; Christopher R Bethel; Jodi M Thomson; Vernon E Anderson; Miriam Barlow; Louis B Rice; Fred C Tenover; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

5.  Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene.

Authors:  L Poirel; T Naas; M Guibert; E B Chaibi; R Labia; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

6.  OXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa.

Authors:  L N Philippon; T Naas; A T Bouthors; V Barakett; P Nordmann
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

7.  Nosocomial multi-drug resistant Acinetobacter baumannii bloodstream infection: risk factors and outcome with ampicillin-sulbactam treatment.

Authors:  R Smolyakov; A Borer; K Riesenberg; F Schlaeffer; M Alkan; A Porath; D Rimar; Y Almog; J Gilad
Journal:  J Hosp Infect       Date:  2003-05       Impact factor: 3.926

8.  Antibacterial in vitro activity of fourth generation cephalosporins.

Authors:  R E Hancock; F Bellido
Journal:  J Chemother       Date:  1996-02       Impact factor: 1.714

9.  Effect of an amino acid insertion into the omega loop region of a class C beta-lactamase on its substrate specificity.

Authors:  M Nukaga; K Taniguchi; Y Washio; T Sawai
Journal:  Biochemistry       Date:  1998-07-21       Impact factor: 3.162

10.  Severe nosocomial infections with imipenem-resistant Acinetobacter baumannii treated with ampicillin/sulbactam.

Authors:  Anna S Levin; Carlos E Levy; A Edison I Manrique; Eduardo A S Medeiros; Silvia F Costa
Journal:  Int J Antimicrob Agents       Date:  2003-01       Impact factor: 5.283
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  27 in total

1.  Co-production of AmpC and extended spectrum beta-lactamases in cephalosporin-resistant Acinetobacter baumannii in Egypt.

Authors:  Heba Shehta Said; Abdalbagi Basheer Benmahmod; Ramadan Hassan Ibrahim
Journal:  World J Microbiol Biotechnol       Date:  2018-12-03       Impact factor: 3.312

2.  Rapidec Carba NP Test for Rapid Detection of Carbapenemase Producers.

Authors:  Laurent Poirel; Patrice Nordmann
Journal:  J Clin Microbiol       Date:  2015-06-17       Impact factor: 5.948

3.  N152G, -S, and -T substitutions in CMY-2 β-lactamase increase catalytic efficiency for cefoxitin and inactivation rates for tazobactam.

Authors:  Marion J Skalweit; Mei Li; Benjamin C Conklin; Magdalena A Taracila; Rebecca A Hutton
Journal:  Antimicrob Agents Chemother       Date:  2013-01-14       Impact factor: 5.191

Review 4.  Epidemiology of β-Lactamase-Producing Pathogens.

Authors:  Karen Bush; Patricia A Bradford
Journal:  Clin Microbiol Rev       Date:  2020-02-26       Impact factor: 26.132

5.  Effect of asparagine substitutions in the YXN loop of a class C β-lactamase of Acinetobacter baumannii on substrate and inhibitor kinetics.

Authors:  Marion J Skalweit; Mei Li; Magda A Taracila
Journal:  Antimicrob Agents Chemother       Date:  2014-12-22       Impact factor: 5.191

6.  Hydrolysis spectrum extension of CMY-2-like β-lactamases resulting from structural alteration in the Y-X-N loop.

Authors:  Sandrine Dahyot; Hedi Mammeri
Journal:  Antimicrob Agents Chemother       Date:  2012-01-09       Impact factor: 5.191

7.  Extended-spectrum AmpC cephalosporinase in Acinetobacter baumannii: ADC-56 confers resistance to cefepime.

Authors:  Guo-Bao Tian; Jennifer M Adams-Haduch; Magdalena Taracila; Robert A Bonomo; Hong-Ning Wang; Yohei Doi
Journal:  Antimicrob Agents Chemother       Date:  2011-07-25       Impact factor: 5.191

8.  Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog.

Authors:  Brandy N Curtis; Kali A Smolen; Sara J Barlow; Emilia Caselli; Fabio Prati; Magdalena A Taracila; Robert A Bonomo; Bradley J Wallar; Rachel A Powers
Journal:  Antimicrob Agents Chemother       Date:  2020-11-17       Impact factor: 5.191

9.  Structure of the extended-spectrum class C β-lactamase ADC-1 from Acinetobacter baumannii.

Authors:  Monolekha Bhattacharya; Marta Toth; Nuno Tiago Antunes; Clyde A Smith; Sergei B Vakulenko
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2014-02-22

Review 10.  Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy.

Authors:  Bora Shin; Woojun Park
Journal:  J Microbiol       Date:  2017-10-27       Impact factor: 3.422
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