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Literature DB >> 20547192

Gold nanoparticle platforms as drug and biomacromolecule delivery systems.

Bradley Duncan¹, Chaekyu Kim¹, Vincent M Rotello².

Abstract

Gold nanoparticles (AuNPs) are a suitable platform for development of efficient delivery systems. AuNPs can be easily synthesized, functionalized, and are biocompatible. The tunability of the AuNP monolayer allows for complete control of surface properties for targeting and stability/release using these nanocarriers. This review will discuss several delivery strategies utilizing AuNPs.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Gold
Glutathione
Cisplatin

Year: 2010 PMID： 20547192 PMCID： PMC2952284 DOI： 10.1016/j.jconrel.2010.06.004

Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776

71 in total

1. Multifunctional gold nanoparticle-peptide complexes for nuclear targeting.

Authors: Alexander G Tkachenko; Huan Xie; Donna Coleman; Wilhelm Glomm; Joseph Ryan; Miles F Anderson; Stefan Franzen; Daniel L Feldheim
Journal: J Am Chem Soc Date: 2003-04-23 Impact factor: 15.419

2. Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant.

Authors: Eun Chul Cho; Jingwei Xie; Patricia A Wurm; Younan Xia
Journal: Nano Lett Date: 2009-03 Impact factor: 11.189

Gold nanoparticle platforms as drug and biomacromolecule delivery systems.

1. Multifunctional gold nanoparticle-peptide complexes for nuclear targeting.

2. Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI etchant.

3. Nanogeometry: beyond drug delivery.

Review 4. Biological properties of "naked" metal nanoparticles.

5. Dendrimers as drug delivery vehicles: non-covalent interactions of bioactive compounds with dendrimers.

6. Polymer size and concentration effects on the size of gold nanoparticles capped by polymeric thiols.

7. Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads.

8. Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells.

Review 9. Nanocarriers as an emerging platform for cancer therapy.

Review 10. Nanoparticle therapeutics: an emerging treatment modality for cancer.

Review 1. Nanoparticle mediated non-covalent drug delivery.

2. The therapeutic efficacy of camptothecin-encapsulated supramolecular nanoparticles.

Review 3. Gold nanoparticles: preparation, properties, and applications in bionanotechnology.

4. Quantifying the coverage density of poly(ethylene glycol) chains on the surface of gold nanostructures.

5. Surface decorated gold nanoparticles by linear and cyclic peptides as molecular transporters.

Review 6. Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light.

7. Inorganic Nanoparticles for Therapeutic Delivery: Trials, Tribulations and Promise.

Review 8. Gold nanoparticles in cancer therapy.

Review 9. DNA nanomaterials for preclinical imaging and drug delivery.

10. Histone-Mimetic Gold Nanoparticles as Versatile Scaffolds for Gene Transfer and Chromatin Analysis.