OBJECTIVES: The study aims to compare the omega-6 (n-6) and omega-3 (n-3) highly unsaturated fatty acids (HUFA), and trans fatty acid (trans FA) status of Complex Regional Pain Syndrome (CRPS) patients to pain-free controls. DESIGN: Case control study. Setting. The setting was at a multidisciplinary rehabilitation center. PATIENTS: Twenty patients that met the Budapest research diagnostic criteria for CRPS and 15 pain-free control subjects were included in this study. Outcome Measures. Fasting plasma fatty acids were collected from all participants. In CRPS patients, pain was assessed using the McGill Pain Questionnaire-Short Form. In addition, results from the perceived disability (Pain Disability Index), pain-related anxiety (Pain Anxiety Symptom Scale Short Form), depression (Center for Epidemiologic Studies Depression Scale Short Form), and quality of life (Short Form-36 [SF-36]) were evaluated. RESULTS: Compared with controls, CRPS patients demonstrated elevated concentrations of n-6 HUFA and trans FA. No differences in n-3 HUFA concentrations were observed. Plasma concentrations of the n-6 HUFA docosatetraenoic acid were inversely correlated with the "vitality" section of the SF-36. Trans FA concentrations positively correlated with pain-related disability and anxiety. CONCLUSION: These pilot data suggest that elevated n-6 HUFA and trans FA may play a role in CRPS pathogenesis. These findings should be replicated, and more research is needed to explore the clinical significance of low n-6 and trans FA diets with or without concurrent n-3 HUFA supplementation, for the management of CRPS.
OBJECTIVES: The study aims to compare the omega-6 (n-6) and omega-3 (n-3) highly unsaturated fatty acids (HUFA), and trans fatty acid (trans FA) status of Complex Regional Pain Syndrome (CRPS) patients to pain-free controls. DESIGN: Case control study. Setting. The setting was at a multidisciplinary rehabilitation center. PATIENTS: Twenty patients that met the Budapest research diagnostic criteria for CRPS and 15 pain-free control subjects were included in this study. Outcome Measures. Fasting plasma fatty acids were collected from all participants. In CRPS patients, pain was assessed using the McGill Pain Questionnaire-Short Form. In addition, results from the perceived disability (Pain Disability Index), pain-related anxiety (Pain Anxiety Symptom Scale Short Form), depression (Center for Epidemiologic Studies Depression Scale Short Form), and quality of life (Short Form-36 [SF-36]) were evaluated. RESULTS: Compared with controls, CRPS patients demonstrated elevated concentrations of n-6 HUFA and trans FA. No differences in n-3 HUFA concentrations were observed. Plasma concentrations of the n-6 HUFA docosatetraenoic acid were inversely correlated with the "vitality" section of the SF-36. Trans FA concentrations positively correlated with pain-related disability and anxiety. CONCLUSION: These pilot data suggest that elevated n-6 HUFA and trans FA may play a role in CRPS pathogenesis. These findings should be replicated, and more research is needed to explore the clinical significance of low n-6 and trans FA diets with or without concurrent n-3 HUFA supplementation, for the management of CRPS.
Authors: Tereza Bautzova; James R F Hockley; Teresa Perez-Berezo; Julien Pujo; Michael M Tranter; Cleo Desormeaux; Maria Raffaella Barbaro; Lilian Basso; Pauline Le Faouder; Corinne Rolland; Pascale Malapert; Aziz Moqrich; Helene Eutamene; Alexandre Denadai-Souza; Nathalie Vergnolle; Ewan St John Smith; David I Hughes; Giovanni Barbara; Gilles Dietrich; David C Bulmer; Nicolas Cenac Journal: Sci Signal Date: 2018-12-18 Impact factor: 8.192
Authors: Christopher E Ramsden; J Douglas Mann; Keturah R Faurot; Chanee Lynch; Syed Taha Imam; Beth A MacIntosh; Joseph R Hibbeln; James Loewke; Sunyata Smith; Rebecca Coble; Chirayath Suchindran; Susan A Gaylord Journal: Trials Date: 2011-04-15 Impact factor: 2.279
Authors: Katherine Castor; Jessica Dawlaty; Xianghong Arakaki; Noah Gross; Yohannes W Woldeamanuel; Michael G Harrington; Robert P Cowan; Alfred N Fonteh Journal: Front Mol Neurosci Date: 2021-08-31 Impact factor: 5.639
Authors: Christopher E Ramsden; Amit Ringel; Sharon F Majchrzak-Hong; Jun Yang; Helene Blanchard; Daisy Zamora; James D Loewke; Stanley I Rapoport; Joseph R Hibbeln; John M Davis; Bruce D Hammock; Ameer Y Taha Journal: Mol Pain Date: 2016-03-10 Impact factor: 3.395