Literature DB >> 20543073

Identification of the biosynthetic gene cluster for the Pseudomonas aeruginosa antimetabolite L-2-amino-4-methoxy-trans-3-butenoic acid.

Xiaoyun Lee1, Aine Fox, Janice Sufrin, Hugues Henry, Paul Majcherczyk, Dieter Haas, Cornelia Reimmann.   

Abstract

L-2-amino-4-methoxy-trans-3-butenoic acid (AMB) is a potent antibiotic and toxin produced by Pseudomonas aeruginosa. Using a novel biochemical assay combined with site-directed mutagenesis in strain PAO1, we have identified a five-gene cluster specifying AMB biosynthesis, probably involving a thiotemplate mechanism. Overexpression of this cluster in strain PA7, a natural AMB-negative isolate, led to AMB overproduction.

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Year:  2010        PMID： 20543073      PMCID： PMC2916419          DOI： 10.1128/JB.00492-10

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


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