Literature DB >> 20542426

Monastrol analogs: a synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screening.

Jan Svetlik1, Lucia Veizerová, Thomas U Mayer, Mario Catarinella.   

Abstract

A synthesis of novel pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged pyrazolo-, tetrazolo-, benzimidazo-, and thiazolopyrimidines via Hantzsch- and Biginelli-like condensations has been developed. The ability of these compounds to inhibit Eg5 activity has been examined. The results indicate that synthetic manipulations in the monastrol thiourea moiety are inefficient. 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20542426     DOI： 10.1016/j.bmcl.2010.05.085

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Multicomponent Synthesis of 2,3-Dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: A Novel Heterocyclic Scaffold with Antibacterial Activity.

Authors:  Liliya V Frolova; Indranil Malik; Pavel Y Uglinskii; Snezna Rogelj; Alexander Kornienko; Igor V Magedov
Journal:  Tetrahedron Lett       Date:  2011-12-07       Impact factor: 2.415

2.  Methyl 5'-(2-hy-droxy-phen-yl)-4',5',6',7'-tetra-hydro-spiro-[2H-1-benzopyran-2,7'-1,2,4-triazolo[1,5-a]pyrimidine]-3-carboxyl-ate.

Authors:  Viktor Kettmann; Jan Světlík
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-12-11

3.  The unexpected influence of aryl substituents in N-aryl-3-oxobutanamides on the behavior of their multicomponent reactions with 5-amino-3-methylisoxazole and salicylaldehyde.

Authors:  Volodymyr V Tkachenko; Elena A Muravyova; Sergey M Desenko; Oleg V Shishkin; Svetlana V Shishkina; Dmytro O Sysoiev; Thomas J J Müller; Valentin A Chebanov
Journal:  Beilstein J Org Chem       Date:  2014-12-17       Impact factor: 2.883

4.  4-Thiazolidinones in heterocyclic synthesis: synthesis of novel enaminones, azolopyrimidines and 2-arylimino-5-arylidene-4-thiazolidinones.

Authors:  Haider Behbehani; Hamada Mohamed Ibrahim
Journal:  Molecules       Date:  2012-05-25       Impact factor: 4.411

5.  Crystal structure and Hirshfeld surface analysis of 7-eth-oxy-5-methyl-2-(pyridin-3-yl)-11,12-di-hydro-5,11-methano-[1,2,4]triazolo[1,5-c][1,3,5]benzoxadiazo-cine.

Authors:  Ercan Aydemir; Sevgi Kansiz; Mustafa Kemal Gumus; Nikolay Yu Gorobets; Necmi Dege
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-02-20
  5 in total

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