Literature DB >> 20542300

Cembranolides from the stem bark of the southern African medicinal plant, Croton gratissimus (Euphorbiaceae).

Dulcie A Mulholland1, Moses K Langat, Neil R Crouch, Helen M Coley, Emily M Mutambi, Jean-Marc Nuzillard.   

Abstract

The stem bark of Croton gratissimus (Euphorbiaceae) yielded four cembranolides, including the first reported example of a 2,12-cyclocembranolide, (+)-[1R*,2S*,7S*,8S*,12R*]-7,8-epoxy-2,12-cyclocembra-3E,10Z-dien-20,10-olide, whose structure was confirmed by means of single crystal X-ray analysis. This compound showed moderate activity against the PEO1 and PEO1TaxR ovarian cancer cell lines. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20542300     DOI： 10.1016/j.phytochem.2010.05.014

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  7 in total

1.  Medicinal plants used for the management of respiratory diseases in Zimbabwe: Review and perspectives potential management of COVID-19.

Authors:  Elliot Nyagumbo; William Pote; Bridgett Shopo; Trust Nyirenda; Ignatius Chagonda; Ruvimbo J Mapaya; Fabian Maunganidze; William N Mavengere; Cephas Mawere; Ian Mutasa; Emmanuel Kademeteme; Alfred Maroyi; Tafadzwa Taderera; Michael Bhebhe
Journal:  Phys Chem Earth (2002)       Date:  2022-09-21       Impact factor: 3.311

Review 2.  Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae).

Authors:  Kirkland Dingili Magwilu; Joseph Mwanzia Nguta; Isaac Mapenay; Dorine Matara
Journal:  Adv Pharmacol Pharm Sci       Date:  2022-05-17

3.  Anti-staphylococcal, anti-HIV and cytotoxicity studies of four South African medicinal plants and isolation of bioactive compounds from Cassine transvaalensis (Burtt. Davy) codd.

Authors:  Ningy S Mthethwa; Bola A O Oyedeji; Larry C Obi; Olayinka A Aiyegoro
Journal:  BMC Complement Altern Med       Date:  2014-12-18       Impact factor: 3.659

4.  Croton gratissimus leaf extracts inhibit cancer cell growth by inducing caspase 3/7 activation with additional anti-inflammatory and antioxidant activities.

Authors:  Emmanuel Mfotie Njoya; Jacobus N Eloff; Lyndy J McGaw
Journal:  BMC Complement Altern Med       Date:  2018-11-14       Impact factor: 3.659

Review 5.  Chemical Constituents from Croton Species and Their Biological Activities.

Authors:  Wen-Hui Xu; Wei-Yi Liu; Qian Liang
Journal:  Molecules       Date:  2018-09-12       Impact factor: 4.411

6.  In vitro antiviral activity of twenty-seven medicinal plant extracts from Southwest Nigeria against three serotypes of echoviruses.

Authors:  Omonike O Ogbole; Toluwanimi E Akinleye; Peter A Segun; Temitope C Faleye; Adekunle J Adeniji
Journal:  Virol J       Date:  2018-07-18       Impact factor: 4.099

7.  Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species.

Authors:  Ashwell R Ndhlala; Mutalib A Aderogba; Bhekumthetho Ncube; Johannes Van Staden
Journal:  Molecules       Date:  2013-02-01       Impact factor: 4.411
  7 in total

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