Literature DB >> 20540093

Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility.

Joost P Bruggeman1, Christopher J Bettinger, Robert Langer.   

Abstract

Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants. Copyright 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.

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Year:  2010        PMID： 20540093      PMCID： PMC2935807          DOI： 10.1002/jbm.a.32733

Source DB:  PubMed          Journal:  J Biomed Mater Res A        ISSN： 1549-3296            Impact factor:   4.396


  20 in total

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Authors:  W F den Dunnen; M F Meek; D W Grijpma; P H Robinson; J M Schakenraad
Journal:  J Biomed Mater Res       Date:  2000-09-15

Review 2.  Small-scale systems for in vivo drug delivery.

Authors:  David A LaVan; Terry McGuire; Robert Langer
Journal:  Nat Biotechnol       Date:  2003-10       Impact factor: 54.908

3.  In vivo degradation behavior of photo-cross-linked star-poly(epsilon-caprolactone-co-D,L-lactide) elastomers.

Authors:  Brian G Amsden; M Yat Tse; Norma D Turner; Darryl K Knight; Stephen C Pang
Journal:  Biomacromolecules       Date:  2006-01       Impact factor: 6.988

4.  US Food and Drug Administration/Conformit Europe-approved absorbable nerve conduits for clinical repair of peripheral and cranial nerves.

Authors:  M F Meek; J H Coert
Journal:  Ann Plast Surg       Date:  2008-01       Impact factor: 1.539

Review 5.  Tissue engineering.

Authors:  R Langer; J P Vacanti
Journal:  Science       Date:  1993-05-14       Impact factor: 47.728

6.  Long-term evaluation of nerve regeneration in a biodegradable nerve guide.

Authors:  W F Den Dunnen; B Van der Lei; J M Schakenraad; E H Blaauw; I Stokroos; A J Pennings; P H Robinson
Journal:  Microsurgery       Date:  1993       Impact factor: 2.425

7.  Synthetic biodegradable polymers as orthopedic devices.

Authors:  J C Middleton; A J Tipton
Journal:  Biomaterials       Date:  2000-12       Impact factor: 12.479

8.  A tough biodegradable elastomer.

Authors:  Yadong Wang; Guillermo A Ameer; Barbara J Sheppard; Robert Langer
Journal:  Nat Biotechnol       Date:  2002-06       Impact factor: 54.908

9.  In vivo degradation characteristics of poly(glycerol sebacate).

Authors:  Yadong Wang; Yu Mi Kim; Robert Langer
Journal:  J Biomed Mater Res A       Date:  2003-07-01       Impact factor: 4.396

10.  Biodegradable poly(polyol sebacate) polymers.

Authors:  Joost P Bruggeman; Berend-Jan de Bruin; Christopher J Bettinger; Robert Langer
Journal:  Biomaterials       Date:  2008-09-27       Impact factor: 12.479
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  5 in total

1.  A highly tunable biocompatible and multifunctional biodegradable elastomer.

Authors:  Maria José Nunes Pereira; Ben Ouyang; Cathryn A Sundback; Nora Lang; Ingeborg Friehs; Shwetha Mureli; Irina Pomerantseva; Jacob McFadden; Mark C Mochel; Olive Mwizerwa; Pedro Del Nido; Debanjan Sarkar; Peter T Masiakos; Robert Langer; Lino S Ferreira; Jeffrey M Karp
Journal:  Adv Mater       Date:  2012-12-12       Impact factor: 30.849

2.  Biodegradable poly(polyol sebacate) polymers.

Authors:  Joost P Bruggeman; Berend-Jan de Bruin; Christopher J Bettinger; Robert Langer
Journal:  Biomaterials       Date:  2008-09-27       Impact factor: 12.479

3.  Progress and challenges in biomaterials used for bone tissue engineering: bioactive glasses and elastomeric composites.

Authors:  Qizhi Chen; Chenghao Zhu; George A Thouas
Journal:  Prog Biomater       Date:  2012-09-26

4.  Effect of E-Beam Irradiation on Thermal and Mechanical Properties of Ester Elastomers Containing Multifunctional Alcohols.

Authors:  Marta Piątek-Hnat; Kuba Bomba; Jakub Pęksiński; Agnieszka Kozłowska; Jacek G Sośnicki; Tomasz J Idzik
Journal:  Polymers (Basel)       Date:  2020-05-02       Impact factor: 4.329

5.  Structure and Properties of Biodegradable Poly (Xylitol Sebacate-Co-Butylene Sebacate) Copolyester.

Authors:  Marta Piątek-Hnat; Kuba Bomba; Jakub Pęksiński
Journal:  Molecules       Date:  2020-03-28       Impact factor: 4.411
  5 in total

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