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Literature DB >> 18824260

Biodegradable poly(polyol sebacate) polymers.

Joost P Bruggeman¹, Berend-Jan de Bruin, Christopher J Bettinger, Robert Langer.

Abstract

We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's moduli ranging from 0.37+/-0.08 to 378+/-33 MPa with maximum elongations at break from 10.90+/-1.37% to 205.16+/-55.76%, and glass transition temperatures ranging from approximately 7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA).

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 18824260 PMCID： PMC2948970 DOI： 10.1016/j.biomaterials.2008.08.037

Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479

24 in total

1. In vivo and in vitro degradation of poly[(50)/(50) ((85)/(15)(L)/(D))LA/epsilon-CL], and the implications for the use in nerve reconstruction.

Authors: W F den Dunnen; M F Meek; D W Grijpma; P H Robinson; J M Schakenraad
Journal: J Biomed Mater Res Date: 2000-09-15

2. Tissue engineering of arteries by directed remodeling of intact arterial segments.

Authors: Valerie Clerin; Jason W Nichol; Matus Petko; Richard J Myung; J William Gaynor; Keith J Gooch
Journal: Tissue Eng Date: 2003-06

Review 3. An evaluation of biochemical aspects of intravenous fructose, sorbitol and xylitol administration in man.

Authors: L Sestoft
Journal: Acta Anaesthesiol Scand Suppl Date: 1985

4. Metabolic response to lactitol and xylitol in healthy men.

Authors: S S Natah; K R Hussien; J A Tuominen; V A Koivisto
Journal: Am J Clin Nutr Date: 1997-04 Impact factor: 7.045

5. A tough biodegradable elastomer.

Authors: Yadong Wang; Guillermo A Ameer; Barbara J Sheppard; Robert Langer
Journal: Nat Biotechnol Date: 2002-06 Impact factor: 54.908

6. Hemocompatibility evaluation of poly(glycerol-sebacate) in vitro for vascular tissue engineering.

Authors: Delara Motlagh; Jian Yang; Karen Y Lui; Antonio R Webb; Guillermo A Ameer
Journal: Biomaterials Date: 2006-05-03 Impact factor: 12.479

7. Microfabrication of poly (glycerol-sebacate) for contact guidance applications.

Authors: Christopher J Bettinger; Brian Orrick; Asish Misra; Robert Langer; Jeffrey T Borenstein
Journal: Biomaterials Date: 2005-12-28 Impact factor: 12.479

8. In vivo degradation characteristics of poly(glycerol sebacate).

Authors: Yadong Wang; Yu Mi Kim; Robert Langer
Journal: J Biomed Mater Res A Date: 2003-07-01 Impact factor: 4.396

9. Amino alcohol-based degradable poly(ester amide) elastomers.

Authors: Christopher J Bettinger; Joost P Bruggeman; Jeffrey T Borenstein; Robert S Langer
Journal: Biomaterials Date: 2008-03-04 Impact factor: 12.479

10. Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue.

Authors: Qi-Zhi Chen; Alexander Bismarck; Ulrich Hansen; Sarah Junaid; Michael Q Tran; Siân E Harding; Nadire N Ali; Aldo R Boccaccini
Journal: Biomaterials Date: 2008-01 Impact factor: 12.479

30 in total

Biodegradable poly(polyol sebacate) polymers.

1. In vivo and in vitro degradation of poly[(50)/(50) ((85)/(15)(L)/(D))LA/epsilon-CL], and the implications for the use in nerve reconstruction.

2. Tissue engineering of arteries by directed remodeling of intact arterial segments.

Review 3. An evaluation of biochemical aspects of intravenous fructose, sorbitol and xylitol administration in man.

4. Metabolic response to lactitol and xylitol in healthy men.

5. A tough biodegradable elastomer.

6. Hemocompatibility evaluation of poly(glycerol-sebacate) in vitro for vascular tissue engineering.

7. Microfabrication of poly (glycerol-sebacate) for contact guidance applications.

8. In vivo degradation characteristics of poly(glycerol sebacate).

9. Amino alcohol-based degradable poly(ester amide) elastomers.

10. Characterisation of a soft elastomer poly(glycerol sebacate) designed to match the mechanical properties of myocardial tissue.

1. Cell-adhesive and mechanically tunable glucose-based biodegradable hydrogels.

2. Super stretchable electroactive elastomer formation driven by aniline trimer self-assembly.

3. Correlation of hydrolytic degradation with structure for copolyesters produced from glycolic and adipic acids.

4. A novel internal fixator device for peripheral nerve regeneration.

5. Elastomeric electrospun scaffolds of poly(L-lactide-co-trimethylene carbonate) for myocardial tissue engineering.

6. A functionalizable polyester with free hydroxyl groups and tunable physiochemical and biological properties.

7. Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility.

8. Microwave-assisted facile fabrication of porous poly (glycerol sebacate) scaffolds.

9. The effect of plasticizers on the erosion and mechanical properties of polymeric films.

Review 10. Recent advances in synthetic bioelastomers.