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Literature DB >> 20539821

Targeted probes for cardiovascular MRI.

Abstract

Molecular MRI plays an important role in studying molecular and cellular processes associated with heart disease. Targeted probes that recognize important biomarkers of atherosclerosis, apoptosis, necrosis, angiogenesis, thrombosis and inflammation have been developed. This review discusses the properties of chemically different contrast agents including iron oxide nanoparticles, gadolinium-based nanoparticles or micelles, discrete peptide conjugates and activatable probes. Numerous examples of contrast agents based on these approaches have been used in preclinical MRI of cardiovascular diseases. Clinical applications are still under investigation for some selected agents with highly promising initial results. Molecular MRI shows great potential for the detection and characterization of a wide range of cardiovascular diseases, as well as for monitoring response to therapy.

Entities: Chemical Disease Gene Species

Keywords: Cardiovascular; MRI; atherosclerosis; gadolinium; iron oxide nanoparticles; micelles; molecular imaging; smart probes; targeted peptides

Mesh：

Substances：

Year: 2010 PMID： 20539821 PMCID： PMC2882676 DOI： 10.4155/FMC.09.154

Source DB: PubMed Journal: Future Med Chem ISSN： 1756-8919 Impact factor: 3.808

94 in total

1. Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON).

Authors: Matthias Stuber; Wesley D Gilson; Michael Schär; Dorota A Kedziorek; Lawrence V Hofmann; Saurabh Shah; Evert-Jan Vonken; Jeff W M Bulte; Dara L Kraitchman
Journal: Magn Reson Med Date: 2007-11 Impact factor: 4.668

2. A paramagnetic contrast agent for detecting tyrosinase activity.

Authors: Manuel Querol; David G Bennett; Christopher Sotak; Hye Won Kang; Alexei Bogdanov
Journal: Chembiochem Date: 2007-09-24 Impact factor: 3.164

Review 3. Chemical exchange saturation transfer contrast agents for magnetic resonance imaging.

Authors: A Dean Sherry; Mark Woods
Journal: Annu Rev Biomed Eng Date: 2008 Impact factor: 9.590

4. Molecular magnetic resonance imaging of pulmonary emboli with a fibrin-specific contrast agent.

Authors: Elmar Spuentrup; Marcus Katoh; Andrea J Wiethoff; Edward C Parsons; Rene M Botnar; Andreas H Mahnken; Rolf W Günther; Arno Buecker
Journal: Am J Respir Crit Care Med Date: 2005-06-03 Impact factor: 21.405

5. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.

Authors: Matthias Nahrendorf; Farouc A Jaffer; Kimberly A Kelly; David E Sosnovik; Elena Aikawa; Peter Libby; Ralph Weissleder
Journal: Circulation Date: 2006-09-25 Impact factor: 29.690

6. In vivo imaging of activated endothelium using an anti-VCAM-1 magnetooptical probe.

Authors: Andrew Tsourkas; Vivek R Shinde-Patil; Kimberly A Kelly; Pratik Patel; Allison Wolley; Jennifer R Allport; Ralph Weissleder
Journal: Bioconjug Chem Date: 2005 May-Jun Impact factor: 4.774

7. MR angiography of aortoiliac occlusive disease: a phase III study of the safety and effectiveness of the blood-pool contrast agent MS-325.

Authors: Mathias Goyen; Mark Edelman; Pierre Perreault; Elaine O'Riordan; Hernan Bertoni; James Taylor; Daniel Siragusa; Melhem Sharafuddin; Emile R Mohler; Robert Breger; E Kent Yucel; Kohkan Shamsi; Robert M Weisskoff
Journal: Radiology Date: 2005-07-14 Impact factor: 11.105

8. Efficiency, thermodynamic and kinetic stability of marketed gadolinium chelates and their possible clinical consequences: a critical review.

Authors: Marc Port; Jean-Marc Idée; Christelle Medina; Caroline Robic; Monique Sabatou; Claire Corot
Journal: Biometals Date: 2008-03-15 Impact factor: 2.949

9. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.

Authors: Matthias Nahrendorf; David Sosnovik; John W Chen; Peter Panizzi; Jose-Luiz Figueiredo; Elena Aikawa; Peter Libby; Filip K Swirski; Ralph Weissleder
Journal: Circulation Date: 2008-02-11 Impact factor: 29.690

10. In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI.

Authors: Rikin A Trivedi; Jean-Marie U-King-Im; Martin J Graves; Justin J Cross; Jo Horsley; Martin J Goddard; Jeremy N Skepper; George Quartey; Elizabeth Warburton; Ilse Joubert; Liqun Wang; Peter J Kirkpatrick; John Brown; Jonathan H Gillard
Journal: Stroke Date: 2004-05-27 Impact factor: 7.914

14 in total

1. Magnetic stents retain nanoparticle-bound antirestenotic drugs transported by lipid microbubbles.

Authors: T Räthel; H Mannell; J Pircher; B Gleich; U Pohl; F Krötz
Journal: Pharm Res Date: 2011-12-22 Impact factor: 4.200

2. 1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging.

Authors: Yan Yang; Daniel T Schühle; Guangping Dai; Jamu K Alford; Peter Caravan
Journal: Contrast Media Mol Imaging Date: 2012 Mar-Apr Impact factor: 3.161

3. Targeted Nanocarriers for Imaging and Therapy of Vascular Inflammation.

Authors: Ann-Marie Chacko; Elizabeth D Hood; Blaine J Zern; Vladimir R Muzykantov
Journal: Curr Opin Colloid Interface Sci Date: 2011-06 Impact factor: 6.448

Review 4. From molecules to myofibers: multiscale imaging of the myocardium.

Authors: Craig J Goergen; David E Sosnovik
Journal: J Cardiovasc Transl Res Date: 2011-06-04 Impact factor: 4.132

5. Receptor-targeted iron oxide nanoparticles for molecular MR imaging of inflamed atherosclerotic plaques.

Authors: Chuqiao Tu; Thomas S C Ng; Hargun K Sohi; Heather A Palko; Adrian House; Russell E Jacobs; Angelique Y Louie
Journal: Biomaterials Date: 2011-07-13 Impact factor: 12.479

6. Human in vitro suppression as screening tool for the recognition of an early state of immune imbalance.

Authors: Jill Waukau; Jeffrey Woodliff; Sanja Glisic
Journal: J Vis Exp Date: 2011-07-22 Impact factor: 1.355

7. Preparation, purification, and characterization of lanthanide complexes for use as contrast agents for magnetic resonance imaging.

Authors: Derek J Averill; Joel Garcia; Buddhima N Siriwardena-Mahanama; Sashiprabha M Vithanarachchi; Matthew J Allen
Journal: J Vis Exp Date: 2011-07-21 Impact factor: 1.355