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Literature DB >> 20538542

TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression.

Abstract

Transforming growth factor beta (TGF-beta) plays an important role in tumor initiation and progression, functioning as both a suppressor and a promoter. The mechanisms underlying this dual role of TGF-beta remain unclear. TGF-beta exerts systemic immune suppression and inhibits host immunosurveillance. Neutralizing TGF-beta enhances CD8+ T-cell- and NK-cell-mediated anti-tumor immune responses. It also increases neutrophil-attracting chemokines resulting in recruitment and activation of neutrophils with an antitumor phenotype. In addition to its systemic effects, TGF-beta regulates infiltration of inflammatory/immune cells and cancer-associated fibroblasts in the tumor microenvironment causing direct changes in tumor cells. Understanding TGF-beta regulation at the interface of tumor and host immunity should provide insights into developing effective TGF-beta antagonists and biomarkers for patient selection and efficacy of TGF-beta antagonist treatment. Published by Elsevier Ltd.

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Year: 2010 PMID： 20538542 PMCID： PMC2891151 DOI： 10.1016/j.it.2010.04.002

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

86 in total

1. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).

Authors: Subhra K Biswas; Lisa Gangi; Saki Paul; Tiziana Schioppa; Alessandra Saccani; Marina Sironi; Barbara Bottazzi; Andrea Doni; Bronte Vincenzo; Fabio Pasqualini; Luca Vago; Manuela Nebuloni; Alberto Mantovani; Antonio Sica
Journal: Blood Date: 2005-11-03 Impact factor: 22.113

Review 2. Inhibition of TGFbeta signaling in cancer therapy.

Authors: Carlos L Arteaga
Journal: Curr Opin Genet Dev Date: 2005-12-27 Impact factor: 5.578

Review 3. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.

Authors: John Condeelis; Jeffrey W Pollard
Journal: Cell Date: 2006-01-27 Impact factor: 41.582

4. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.

Authors: Dori A Thomas; Joan Massagué
Journal: Cancer Cell Date: 2005-11 Impact factor: 31.743

5. The dual adverse effects of TGF-beta secretion on tumor progression.

Authors: Joseph A Trapani
Journal: Cancer Cell Date: 2005-11 Impact factor: 31.743

6. Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice.

Authors: Lillian Maggio-Price; Piper Treuting; Weiping Zeng; Mark Tsang; Helle Bielefeldt-Ohmann; Brian M Iritani
Journal: Cancer Res Date: 2006-01-15 Impact factor: 12.701

7. Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.

Authors: Yasmina Laouar; Fayyaz S Sutterwala; Leonid Gorelik; Richard A Flavell
Journal: Nat Immunol Date: 2005-04-24 Impact factor: 25.606

8. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent.

Authors: Karin E de Visser; Lidiya V Korets; Lisa M Coussens
Journal: Cancer Cell Date: 2005-05 Impact factor: 31.743

9. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

Authors: Marc Veldhoen; Richard J Hocking; Christopher J Atkins; Richard M Locksley; Brigitta Stockinger
Journal: Immunity Date: 2006-02 Impact factor: 31.745

10. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner.

Authors: François Ghiringhelli; Cédric Ménard; Magali Terme; Caroline Flament; Julien Taieb; Nathalie Chaput; Pierre E Puig; Sophie Novault; Bernard Escudier; Eric Vivier; Axel Lecesne; Caroline Robert; Jean-Yves Blay; Jacky Bernard; Sophie Caillat-Zucman; Antonio Freitas; Thomas Tursz; Orianne Wagner-Ballon; Claude Capron; William Vainchencker; François Martin; Laurence Zitvogel
Journal: J Exp Med Date: 2005-10-17 Impact factor: 14.307

343 in total

Review 1. Role of TLR2-dependent inflammation in metastatic progression.

Authors: Sunhwa Kim; Michael Karin
Journal: Ann N Y Acad Sci Date: 2011-01 Impact factor: 5.691

Review 2. Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases.

Authors: Paola Nisticò; Mina J Bissell; Derek C Radisky
Journal: Cold Spring Harb Perspect Biol Date: 2012-02-01 Impact factor: 10.005

Review 3. Adoptive T-Cell Immunotherapy.

Authors: Stephen Gottschalk; Cliona M Rooney
Journal: Curr Top Microbiol Immunol Date: 2015 Impact factor: 4.291

TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression.

1. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).

Review 2. Inhibition of TGFbeta signaling in cancer therapy.

Review 3. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.

4. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.

5. The dual adverse effects of TGF-beta secretion on tumor progression.

6. Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice.

7. Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.

8. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent.

9. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

10. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner.

Review 1. Role of TLR2-dependent inflammation in metastatic progression.

Review 2. Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases.

Review 3. Adoptive T-Cell Immunotherapy.

4. Development of a Tumor-Responsive Nanopolyplex Targeting Pancreatic Cancer Cells and Stroma.

Review 5. Advances in the development of cancer immunotherapies.

6. Tumor-infiltrating myeloid cells activate Dll4/Notch/TGF-β signaling to drive malignant progression.

Review 7. Cancer-associated fibroblasts in hepatocellular carcinoma.

8. Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis.

9. Cancer stem cell hypothesis: a brief summary and two proposals.

10. Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance.