Literature DB >> 20536419

Recent advances in the medicinal chemistry of novel erythromycin-derivatized antibiotics.

Lu Ying1, Datong Tang.   

Abstract

Development of novel erythromycin-based antibiotics has been one of the most studied topics in the past three decades. Such tremendous efforts have generated a number of beneficiary drugs such as clarithromycin, azithromycin and telithromycin. However, widespread application of antibiotics in clinical practice has triggered an increasing emergence of bacterial resistance. Therefore, discovery of novel macrolide antibiotics to suppress the resistance is urgent for human healthcare. This review focuses on advances in the area since 2004.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20536419     DOI： 10.2174/156802610792232042

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  5 in total

1.  Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens.

Authors:  Samer S Daher; Xiao Jin; Jimmy Patel; Joel S Freundlich; Bettina Buttaro; Rodrigo B Andrade
Journal:  Bioorg Med Chem Lett       Date:  2019-03-26       Impact factor: 2.823

2.  Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides.

Authors:  Nelli F Khabibullina; Andrey G Tereshchenkov; Ekaterina S Komarova; Egor A Syroegin; Dmitrii I Shiriaev; Alena Paleskava; Victor G Kartsev; Alexey A Bogdanov; Andrey L Konevega; Olga A Dontsova; Petr V Sergiev; Ilya A Osterman; Yury S Polikanov
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

3.  Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket.

Authors:  Colin J B Harvey; Joseph D Puglisi; Vijay S Pande; David E Cane; Chaitan Khosla
Journal:  J Am Chem Soc       Date:  2012-07-11       Impact factor: 15.419

4.  Insights into the mode of action of novel fluoroketolides, potent inhibitors of bacterial protein synthesis.

Authors:  Marios G Krokidis; Viter Márquez; Daniel N Wilson; Dimitrios L Kalpaxis; George P Dinos
Journal:  Antimicrob Agents Chemother       Date:  2013-11-04       Impact factor: 5.191

5.  Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.

Authors:  Evgeny B Pichkur; Alena Paleskava; Andrey G Tereshchenkov; Pavel Kasatsky; Ekaterina S Komarova; Dmitrii I Shiriaev; Alexey A Bogdanov; Olga A Dontsova; Ilya A Osterman; Petr V Sergiev; Yury S Polikanov; Alexander G Myasnikov; Andrey L Konevega
Journal:  RNA       Date:  2020-03-06       Impact factor: 4.942
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.