Literature DB >> 20534339

HAT trick: p300, small molecule, inhibitor.

Melanie Ott1, Eric Verdin.   

Abstract

p300 is an acetyltransferase that targets histone and nonhistone proteins for lysine acetylation. Based on a p300 structure, Bowers et al. (2010) have conducted an in silico screen for active site small molecule inhibitors of p300. We describe this important discovery and its potential therapeutic applications. 2010 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2010        PMID： 20534339     DOI： 10.1016/j.chembiol.2010.05.002

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


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  4 in total

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