OBJECTIVES: Oxidative stress plays a crucial role in the development of diabetic complications. The aims of this study were to investigate whether honey could reduce hyperglycemia and ameliorate oxidative stress in kidneys of streptozotocin-induced diabetic rats. METHODS: Diabetes was induced by a single dose of STZ (60 mg/kg; i. p.). Diabetic rats were randomly grouped and administered distilled water (0.5 mL/day) and honey (0.2 g/kg/day, 1.2 g/kg/day and 2.4 g/kg/day) by oral gavage for four weeks. Each group consisted of six rats. RESULTS: Total antioxidant status (TAS), activities of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST) were significantly reduced, while superoxide dismutase (SOD) activity was up-regulated in kidneys of diabetic rats. Lipid peroxidation (TBARS) and fasting plasma glucose (FPG) were significantly elevated while body weight was reduced in diabetic rats. Honey significantly increased body weight, TAS, activities of CAT, GPx, GR, and GST in diabetic rats. It significantly restored SOD activity, and reduced FPG and TBARS levels in diabetic rats. Histopathological examinations of the kidneys revealed that mesangial matrix expansion and thickening of glomerular basement membrane were reduced in the honey-treated diabetic rats. CONCLUSIONS: Honey exerts a hypoglycemic effect and ameliorates oxidative stress in kidneys of streptozotocin-induced diabetic rats.
OBJECTIVES: Oxidative stress plays a crucial role in the development of diabetic complications. The aims of this study were to investigate whether honey could reduce hyperglycemia and ameliorate oxidative stress in kidneys of streptozotocin-induced diabeticrats. METHODS:Diabetes was induced by a single dose of STZ (60 mg/kg; i. p.). Diabeticrats were randomly grouped and administered distilled water (0.5 mL/day) and honey (0.2 g/kg/day, 1.2 g/kg/day and 2.4 g/kg/day) by oral gavage for four weeks. Each group consisted of six rats. RESULTS: Total antioxidant status (TAS), activities of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione-S-transferase (GST) were significantly reduced, while superoxide dismutase (SOD) activity was up-regulated in kidneys of diabeticrats. Lipid peroxidation (TBARS) and fasting plasma glucose (FPG) were significantly elevated while body weight was reduced in diabeticrats. Honey significantly increased body weight, TAS, activities of CAT, GPx, GR, and GST in diabeticrats. It significantly restored SOD activity, and reduced FPG and TBARS levels in diabeticrats. Histopathological examinations of the kidneys revealed that mesangial matrix expansion and thickening of glomerular basement membrane were reduced in the honey-treated diabeticrats. CONCLUSIONS: Honey exerts a hypoglycemic effect and ameliorates oxidative stress in kidneys of streptozotocin-induced diabeticrats.
Authors: L C Cruz; A Ecker; R S Dias; R L Seeger; M M Braga; A A Boligon; I K Martins; D G Costa-Silva; N V Barbosa; A D Cañedo; T Posser; J L Franco Journal: Neurochem Res Date: 2015-10-30 Impact factor: 3.996
Authors: Amal A Aloud; Chinnadurai Veeramani; Chandramohan Govindasamy; Mohammed A Alsaif; Ahmed S El Newehy; Khalid S Al-Numair Journal: Redox Rep Date: 2016-12-28 Impact factor: 4.412
Authors: Nadia Mohd Effendy; Norazlina Mohamed; Norliza Muhammad; Isa Naina Mohamad; Ahmad Nazrun Shuid Journal: Evid Based Complement Alternat Med Date: 2012-08-29 Impact factor: 2.629