OBJECTIVE: To examine the effect of galangin on hyperglycemia-mediated oxidative stress in streptozotocin (STZ)-induced diabetic rats. METHODS: Diabetes was induced by intraperitoneal administration of low-dose STZ (40 mg/kg body weight (BW)) into male albino Wistar rats. Galangin (8 mg/kg BW) or glibenclamide (600 µg/kg BW) was given orally, once daily for 45 days to normal and STZ-induced diabetic rats. RESULTS: Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, lipid hydroperoxides, and conjugated dienes. The levels of insulin and non-enzymatic antioxidants (vitamin C, vitamin E, reduced glutathione) and the activity of enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase (GST)) were decreased significantly in diabetic control rats. These altered plasma glucose, insulin, lipid peroxidation products, enzymatic and non-enzymatic antioxidants ions were reverted to near-normal level after the administration of galangin and glibenclamide. CONCLUSION: The present study shows that galangin decreased oxidative stress and increased antioxidant status in diabetic rats, which may be due to its antidiabetic and antioxidant potential.
OBJECTIVE: To examine the effect of galangin on hyperglycemia-mediated oxidative stress in streptozotocin (STZ)-induced diabeticrats. METHODS:Diabetes was induced by intraperitoneal administration of low-dose STZ (40 mg/kg body weight (BW)) into male albino Wistar rats. Galangin (8 mg/kg BW) or glibenclamide (600 µg/kg BW) was given orally, once daily for 45 days to normal and STZ-induced diabeticrats. RESULTS:Diabeticrats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, lipid hydroperoxides, and conjugated dienes. The levels of insulin and non-enzymatic antioxidants (vitamin C, vitamin E, reduced glutathione) and the activity of enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase (GST)) were decreased significantly in diabetic control rats. These altered plasma glucose, insulin, lipid peroxidation products, enzymatic and non-enzymatic antioxidants ions were reverted to near-normal level after the administration of galangin and glibenclamide. CONCLUSION: The present study shows that galangin decreased oxidative stress and increased antioxidant status in diabeticrats, which may be due to its antidiabetic and antioxidant potential.
Authors: María Alejandra Sánchez-Muñoz; Mónica Andrea Valdez-Solana; Mara Ibeth Campos-Almazán; Óscar Flores-Herrera; Mercedes Esparza-Perusquía; Sofia Olvera-Sánchez; Guadalupe García-Arenas; Claudia Avitia-Domínguez; Alfredo Téllez-Valencia; Erick Sierra-Campos Journal: Biochem Res Int Date: 2018-03-01
Authors: Amal A Aloud; Veeramani Chinnadurai; Chandramohan Govindasamy; Mohammed A Alsaif; Khalid S Al-Numair Journal: Pharm Biol Date: 2018-12 Impact factor: 3.503
Authors: Amal A Aloud; Chinnadurai Veeramani; Chandramohan Govindasamy; Mohammed A Alsaif; Khalid S Al-Numair Journal: Redox Rep Date: 2017-08-16 Impact factor: 4.412
Authors: Saleem H Aladaileh; Mohammad H Abukhalil; Sultan A M Saghir; Hamza Hanieh; Manal A Alfwuaires; Amer A Almaiman; May Bin-Jumah; Ayman M Mahmoud Journal: Biomolecules Date: 2019-08-05