Literature DB >> 2053292

Inhibition of duck hepatitis B virus infection by lysosomotropic agents.

W B Offensperger1, S Offensperger, E Walter, H E Blum, W Gerok.   

Abstract

The early phases of hepadnaviral infection were studied in primary duck hepatocyte cultures. Incubation of duck hepatocytes in vitro with duck hepatitis B virus (DHBV) resulted in infection with high levels of viral replication. The lysosomotropic agents ammonium chloride and chloroquine effectively inhibited viral infection, indicating that DHBV infection, similar to infection with other enveloped viruses, depends on receptor-mediated endocytosis and involves membrane fusion triggered by low pH.

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Year:  1991        PMID： 2053292     DOI： 10.1016/0042-6822(91)90157-7

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  16 in total

Review 1.  Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism.

Authors:  Anneke Funk; Mouna Mhamdi; Hans Will; Hüseyin Sirma
Journal:  World J Gastroenterol       Date:  2007-01-07       Impact factor: 5.742

Review 2.  Viral and cellular determinants involved in hepadnaviral entry.

Authors:  Dieter Glebe; Stephan Urban
Journal:  World J Gastroenterol       Date:  2007-01-07       Impact factor: 5.742

3.  Sulfated polyanions do not inhibit duck hepatitis B virus infection.

Authors:  W B Offensperger; S Offensperger; E Walter; H E Blum; W Gerok
Journal:  Antimicrob Agents Chemother       Date:  1991-11       Impact factor: 5.191

4.  Duck hepatitis B virus infection of hepatocytes is not dependent on low pH.

Authors:  R J Rigg; H Schaller
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

5.  Uptake of duck hepatitis B virus into hepatocytes occurs by endocytosis but does not require passage of the virus through an acidic intracellular compartment.

Authors:  J Köck; E M Borst; H J Schlicht
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

6.  Topology of the large envelope protein of duck hepatitis B virus suggests a mechanism for membrane translocation during particle morphogenesis.

Authors:  J T Guo; J C Pugh
Journal:  J Virol       Date:  1997-02       Impact factor: 5.103

7.  Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo.

Authors:  P Hafkemeyer; A Keppler-Hafkemeyer; M A al Haya; M von Janta-Lipinski; E Matthes; C Lehmann; W B Offensperger; S Offensperger; W Gerok; H E Blum
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

8.  Suramin prevents duck hepatitis B virus infection in vivo.

Authors:  W B Offensperger; S Offensperger; E Walter; H E Blum; W Gerok
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

9.  HBV life cycle: entry and morphogenesis.

Authors:  Stephanie Schädler; Eberhard Hildt
Journal:  Viruses       Date:  2009-09-01       Impact factor: 5.048

10.  In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides.

Authors:  W B Offensperger; S Offensperger; E Walter; K Teubner; G Igloi; H E Blum; W Gerok
Journal:  EMBO J       Date:  1993-03       Impact factor: 11.598
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