OBJECTIVES: To describe 2-year neurodevelopmental outcome (NDO) in a cohort of extremely low birthweight infants, and compare NDO between two consecutive 5-year periods and between appropriate (AGA, ≥p10) and small for gestational age (SGA, <p10) infants. DESIGN: Retrospective cohort study. SETTING: Wilhelmina Children's Hospital, Utrecht, the Netherlands. PATIENTS: 146 children, born between 1996 and 2005, with a birth weight ≤750 g and a gestational age ≥24 weeks, admitted to the neonatal intensive care unit. 111 children (76%) survived the neonatal period. INTERVENTIONS: At 2 years corrected age, 101 children (cohort I: born in 1996-2000, n=45 and cohort II: born in 2001-2005, n=56) were assessed with either the Griffiths Mental Developmental Scales or the Mental Scale of the Bayley Scales of Infant Development, second edition. MAIN OUTCOME MEASURES: NDO, classified as normal (≤-1 Z score ≥0), mildly delayed (>-1 Z score ≤-2) or severely delayed (Z score >-2). RESULTS: 74.3% of the children had a normal NDO at 2 years corrected age, 20.8% a mildly and 5% a severely delayed outcome. Although survival significantly increased with time (65.8% to 88.1%, p=0.002), significantly fewer children in cohort II (66.1% vs 84.4% in cohort I, p=0.042) as well as fewer SGA children (64.3% vs 86.7% of AGA children, p=0.012) had a normal NDO. CONCLUSIONS: Increased survival of infants with a birth weight ≤750 g coincided with more children with an impaired NDO at 2 years corrected age. SGA infants are especially at risk of impaired NDO.
OBJECTIVES: To describe 2-year neurodevelopmental outcome (NDO) in a cohort of extremely low birthweight infants, and compare NDO between two consecutive 5-year periods and between appropriate (AGA, ≥p10) and small for gestational age (SGA, <p10) infants. DESIGN: Retrospective cohort study. SETTING: Wilhelmina Children's Hospital, Utrecht, the Netherlands. PATIENTS: 146 children, born between 1996 and 2005, with a birth weight ≤750 g and a gestational age ≥24 weeks, admitted to the neonatal intensive care unit. 111 children (76%) survived the neonatal period. INTERVENTIONS: At 2 years corrected age, 101 children (cohort I: born in 1996-2000, n=45 and cohort II: born in 2001-2005, n=56) were assessed with either the Griffiths Mental Developmental Scales or the Mental Scale of the Bayley Scales of Infant Development, second edition. MAIN OUTCOME MEASURES: NDO, classified as normal (≤-1 Z score ≥0), mildly delayed (>-1 Z score ≤-2) or severely delayed (Z score >-2). RESULTS: 74.3% of the children had a normal NDO at 2 years corrected age, 20.8% a mildly and 5% a severely delayed outcome. Although survival significantly increased with time (65.8% to 88.1%, p=0.002), significantly fewer children in cohort II (66.1% vs 84.4% in cohort I, p=0.042) as well as fewer SGA children (64.3% vs 86.7% of AGA children, p=0.012) had a normal NDO. CONCLUSIONS: Increased survival of infants with a birth weight ≤750 g coincided with more children with an impaired NDO at 2 years corrected age. SGA infants are especially at risk of impaired NDO.
Authors: Noelle Younge; Ricki F Goldstein; Carla M Bann; Susan R Hintz; Ravi M Patel; P Brian Smith; Edward F Bell; Matthew A Rysavy; Andrea F Duncan; Betty R Vohr; Abhik Das; Ronald N Goldberg; Rosemary D Higgins; C Michael Cotten Journal: N Engl J Med Date: 2017-02-16 Impact factor: 91.245
Authors: Nazakat M Merchant; Denis V Azzopardi; Ahmed F Hawwa; James C McElnay; Benita Middleton; J Arendt; Tomoki Arichi; Pierre Gressens; A David Edwards Journal: Br J Clin Pharmacol Date: 2013-11 Impact factor: 4.335
Authors: C M C Frank; P G J Nikkels; J C Harteman; I C van Haastert; M J N L Benders; C Koopman-Esseboom; L S de Vries; F Groenendaal Journal: J Perinatol Date: 2016-08-18 Impact factor: 2.521
Authors: Cigdem Tosun; Michael T Koltz; David B Kurland; Hina Ijaz; Melda Gurakar; Gary Schwartzbauer; Turhan Coksaygan; Svetlana Ivanova; Volodymyr Gerzanich; J Marc Simard Journal: Brain Sci Date: 2013-03-07