Literature DB >> 20529682

Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei.

Igor Ngantchou1, Barthélemy Nyasse, Colette Denier, Casimir Blonski, Véronique Hannaert, Bernd Schneider.   

Abstract

In continuation of our study on medicinal plants of Cameroon, stem barks of Polyalthia suaveolens were phytochemically studied. This investigation yielded a new indolosesquiterpene alkaloid, named polysin (1) and four hitherto known alkaloids (2-5). Polysin (1) appeared as a competitive reversible inhibitor (K(i)=10 microM) of phosphofructo kinase (PFK) of Trypanosoma brucei with respect to fructose-6-phosphate (K(i)/K(M)=0.05) and could be used in the design of new trypanocidal drugs. The other isolated compounds (2-5) also exhibited interesting inhibitory effects on selected glycolytic enzymes (PFK, glyceraldehyde-3-phosphate dehydrogenase and aldolase). Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20529682     DOI： 10.1016/j.bmcl.2010.04.145

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

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Journal:  Chemistry       Date:  2014-01-30       Impact factor: 5.236

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4.  Cameroonian medicinal plants: pharmacology and derived natural products.

Authors:  Victor Kuete; Thomas Efferth
Journal:  Front Pharmacol       Date:  2010-10-25       Impact factor: 5.810

Review 5.  Recent metal-catalysed approaches for the synthesis of cyclopenta[b]indoles.

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Journal:  RSC Adv       Date:  2018-05-22       Impact factor: 4.036

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Review 8.  Recent advances on the use of biochemical extracts as filaricidal agents.

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Review 9.  Indole alkaloids from marine sources as potential leads against infectious diseases.

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Review 10.  Kinases as druggable targets in trypanosomatid protozoan parasites.

Authors:  Christopher Merritt; Lisseth E Silva; Angela L Tanner; Kenneth Stuart; Michael P Pollastri
Journal:  Chem Rev       Date:  2014-10-07       Impact factor: 60.622
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