BACKGROUND: Although quantitative evidence is lacking, it is generally believed that the majority of cases of transfusion-related acute lung injury (TRALI) are caused by female blood donors. We aimed to examine the relation between female donors and the occurrence of TRALI. STUDY DESIGN AND METHODS: We performed an international, multicenter case-referent study. TRALI patients who were diagnosed clinically, independent of serology or donor sex, and had received transfusions either only from male donors or only from female donors (unisex cases) were selected. The observed sex distribution among the donors of these TRALI patients was compared to the expected sex distribution, based on the relevant donor populations. RESULTS: Eighty-three clinical TRALI cases were included; 67 cases received only red blood cells (RBCs), 13 only plasma-rich products, and three both. Among RBC recipients the relative risk (RR) of TRALI after a transfusion from a female donor was 1.2 (95% confidence interval [CI], 0.69-2.1) and among plasma-rich product recipients the RR was 19 (95% CI, 1.9-191). The p value for the difference between RBCs and plasma was 0.023. CONCLUSION: Our data support the notion that plasma from female donors is associated with an increased risk of TRALI, while RBCs from female donors are not.
BACKGROUND: Although quantitative evidence is lacking, it is generally believed that the majority of cases of transfusion-related acute lung injury (TRALI) are caused by female blood donors. We aimed to examine the relation between female donors and the occurrence of TRALI. STUDY DESIGN AND METHODS: We performed an international, multicenter case-referent study. TRALI patients who were diagnosed clinically, independent of serology or donor sex, and had received transfusions either only from male donors or only from female donors (unisex cases) were selected. The observed sex distribution among the donors of these TRALI patients was compared to the expected sex distribution, based on the relevant donor populations. RESULTS: Eighty-three clinical TRALI cases were included; 67 cases received only red blood cells (RBCs), 13 only plasma-rich products, and three both. Among RBC recipients the relative risk (RR) of TRALI after a transfusion from a female donor was 1.2 (95% confidence interval [CI], 0.69-2.1) and among plasma-rich product recipients the RR was 19 (95% CI, 1.9-191). The p value for the difference between RBCs and plasma was 0.023. CONCLUSION: Our data support the notion that plasma from female donors is associated with an increased risk of TRALI, while RBCs from female donors are not.
Authors: Rutger A Middelburg; Saskia le Cessie; Ernest Briët; Jan P Vandenbroucke; Johanna G van der Bom Journal: Transfusion Date: 2010-09 Impact factor: 3.157
Authors: Anne F Eder; Ross Herron; Annie Strupp; Beth Dy; Edward P Notari; Linda A Chambers; Roger Y Dodd; Richard J Benjamin Journal: Transfusion Date: 2007-04 Impact factor: 3.157
Authors: R Boulton-Jones; A Norris; A O'Sullivan; A Comrie; M Forgan; P S M Rawlinson; P Clark Journal: Transfus Med Date: 2003-06 Impact factor: 2.019
Authors: Stephen E Wright; Christopher P Snowden; Sally C Athey; Alice A Leaver; Jill-Marie Clarkson; Catherine E Chapman; David R D Roberts; Jonathan P Wallis Journal: Crit Care Med Date: 2008-06 Impact factor: 7.598
Authors: Camila Caram-Deelder; Aukje L Kreuger; Dorothea Evers; Karen M K de Vooght; Daan van de Kerkhof; Otto Visser; Nathalie C V Péquériaux; Francisca Hudig; Jaap Jan Zwaginga; Johanna G van der Bom; Rutger A Middelburg Journal: JAMA Date: 2017-10-17 Impact factor: 56.272
Authors: Alexander P J Vlaar; Pearl Toy; Mark Fung; Mark R Looney; Nicole P Juffermans; Juergen Bux; Paula Bolton-Maggs; Anna L Peters; Christopher C Silliman; Daryl J Kor; Steve Kleinman Journal: Transfusion Date: 2019-04-16 Impact factor: 3.157