Literature DB >> 20521162

The effect of fat intake and antihypertensive drug therapy on serum lipid profile: a cross-sectional survey of serum lipids in male and female hypertensives.

Rakesh Sharma1, T C Raghuram, U Brahmoji Rao, Robert J Moffatt, Kamla Krishnaswamy.   

Abstract

The present study aimed to investigate the effect of betablocker with diuretics therapy on serum cholesterol and high density lipoprotein (HDL-C) lipids in cross-sectional data (age, sex, weight, and body mass index (BMI), smoking/alcoholic consumption) and supplemented vegetarian low-fat diet with daily low fat energy intake, salt intake, duration of drug therapy, and serum protein as effective measures of lowering blood pressure among hypertensives in both males and females. Hypertensive patients on betablocker and/or thiazide therapy were compared in cross-section study with their age, blood pressure, fat intake, serum lipid profile, BMI, and serum albumin in males and females. Dietary fat intake and serum lipid profile were income related. Betablocker and diuretics therapy in combination with dietary fat intervention was beneficial for prolonged dyslipidemia control. Serum cholesterol level was main contributing factor dependent on BMI, duration of drug, and socio-economic factors. Fat intake contributed in hypertension and serum cholesterol levels. A cross-sectional data analysis showed beneficial effects of "low fat-salt-smoking-alcohol consumption and combined polyunsaturated fatty acid with antihypertensive therapy approach" to keep normal dyslipidemia and hypertension. Low fat intake, low salt, smoking, alcohol consumption, and combination of dietary oil supplements with lipid betablockers and diuretic modulators were associated with low hypertension and controlled dyslipidemia in Asian sedentary population.

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Year:  2010        PMID: 20521162     DOI: 10.1007/s11010-010-0496-4

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN: 0300-8177            Impact factor:   3.396


  33 in total

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Authors: 
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7.  Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study.

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Journal:  Drug Saf       Date:  1996-06       Impact factor: 5.606

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Authors:  Harold E Bays
Journal:  Am J Cardiol       Date:  2006-11-28       Impact factor: 2.778

10.  Effect of sesame oil on diuretics or Beta-blockers in the modulation of blood pressure, anthropometry, lipid profile, and redox status.

Authors:  D Sankar; M Ramakrishna Rao; G Sambandam; K V Pugalendi
Journal:  Yale J Biol Med       Date:  2006-03
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  1 in total

1.  Myocardial NOS activity and connexin-43 expression in untreated and omega-3 fatty acids-treated spontaneously hypertensive and hereditary hypertriglyceridemic rats.

Authors:  Jana Radosinska; Barbara Bacova; Iveta Bernatova; Jana Navarova; Anna Zhukovska; Angela Shysh; Ludmila Okruhlicova; Narcis Tribulova
Journal:  Mol Cell Biochem       Date:  2010-10-21       Impact factor: 3.396

  1 in total

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