Literature DB >> 20520658

The quest to understand heterotrimeric G protein signaling.

John J G Tesmer1.   

Abstract

Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein-coupled receptors (GPCRs) remains obscure. Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs.

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Year:  2010        PMID： 20520658      PMCID： PMC2954486          DOI： 10.1038/nsmb0610-650

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  25 in total

1.  Crystal structure of rhodopsin: A G protein-coupled receptor.

Authors:  K Palczewski; T Kumasaka; T Hori; C A Behnke; H Motoshima; B A Fox; I Le Trong; D C Teller; T Okada; R E Stenkamp; M Yamamoto; M Miyano
Journal:  Science       Date:  2000-08-04       Impact factor: 47.728

Review 2.  G proteins.

Authors:  J R Hepler; A G Gilman
Journal:  Trends Biochem Sci       Date:  1992-10       Impact factor: 13.807

Review 3.  Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.

Authors:  Terry Kenakin; Laurence J Miller
Journal:  Pharmacol Rev       Date:  2010-04-14       Impact factor: 25.468

4.  Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.

Authors:  William M Oldham; Ned Van Eps; Anita M Preininger; Wayne L Hubbell; Heidi E Hamm
Journal:  Nat Struct Mol Biol       Date:  2006-08-06       Impact factor: 15.369

Review 5.  Structural basis of function in heterotrimeric G proteins.

Authors:  William M Oldham; Heidi E Hamm
Journal:  Q Rev Biophys       Date:  2006-08-21       Impact factor: 5.318

6.  The regulatory role of adenosine-3', 5'-phosphate.

Authors:  T W RALL; E W SUTHERLAND
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1961

7.  The receptor-bound "empty pocket" state of the heterotrimeric G-protein alpha-subunit is conformationally dynamic.

Authors:  Najmoutin G Abdulaev; Tony Ngo; Eva Ramon; Danielle M Brabazon; John P Marino; Kevin D Ridge
Journal:  Biochemistry       Date:  2006-10-31       Impact factor: 3.162

8.  Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin.

Authors:  D L Farrens; C Altenbach; K Yang; W L Hubbell; H G Khorana
Journal:  Science       Date:  1996-11-01       Impact factor: 47.728

9.  Potent peptide analogues of a G protein receptor-binding region obtained with a combinatorial library.

Authors:  E L Martin; S Rens-Domiano; P J Schatz; H E Hamm
Journal:  J Biol Chem       Date:  1996-01-05       Impact factor: 5.157

10.  A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.

Authors:  Matthew R Whorton; Michael P Bokoch; Søren G F Rasmussen; Bo Huang; Richard N Zare; Brian Kobilka; Roger K Sunahara
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-23       Impact factor: 11.205
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  26 in total

1.  Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit.

Authors:  Ned Van Eps; Anita M Preininger; Nathan Alexander; Ali I Kaya; Scott Meier; Jens Meiler; Heidi E Hamm; Wayne L Hubbell
Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-23       Impact factor: 11.205

2.  Pivotal role of extended linker 2 in the activation of Gα by G protein-coupled receptor.

Authors:  Jianyun Huang; Yutong Sun; J Jillian Zhang; Xin-Yun Huang
Journal:  J Biol Chem       Date:  2014-11-20       Impact factor: 5.157

3.  Ste18p is a positive control element in the mating process of Candida albicans.

Authors:  Hui Lu; Yuan Sun; Yuan-Ying Jiang; Malcolm Whiteway
Journal:  Eukaryot Cell       Date:  2014-01-31

Review 4.  Genetic variants conferring susceptibility to gastroschisis: a phenomenon restricted to the interaction with the environment?

Authors:  Victor M Salinas-Torres; Rafael A Salinas-Torres; Ricardo M Cerda-Flores; Laura E Martínez-de-Villarreal
Journal:  Pediatr Surg Int       Date:  2018-03-17       Impact factor: 1.827

5.  Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution.

Authors:  Matthias Hillenbrand; Christian Schori; Jendrik Schöppe; Andreas Plückthun
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-02       Impact factor: 11.205

6.  Differential light-induced responses in sectorial inherited retinal degeneration.

Authors:  Eva Ramon; Arnau Cordomí; Mònica Aguilà; Sundaramoorthy Srinivasan; Xiaoyun Dong; Anthony T Moore; Andrew R Webster; Michael E Cheetham; Pere Garriga
Journal:  J Biol Chem       Date:  2014-10-30       Impact factor: 5.157

Review 7.  Nanobody stabilization of G protein-coupled receptor conformational states.

Authors:  Jan Steyaert; Brian K Kobilka
Journal:  Curr Opin Struct Biol       Date:  2011-07-21       Impact factor: 6.809

Review 8.  G protein-coupled receptors--recent advances.

Authors:  Dorota Latek; Anna Modzelewska; Bartosz Trzaskowski; Krzysztof Palczewski; Sławomir Filipek
Journal:  Acta Biochim Pol       Date:  2012-12-18       Impact factor: 2.149

9.  Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.

Authors:  Yuanchao Ye; Zhizeng Sun; Ang Guo; Long-Sheng Song; Justin L Grobe; Songhai Chen
Journal:  Cell Signal       Date:  2014-08-02       Impact factor: 4.315

10.  A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization.

Authors:  Anthony P Leonard; Kathryn M Appleton; Louis M Luttrell; Yuri K Peterson
Journal:  Microsc Microanal       Date:  2013-01-28       Impact factor: 4.127
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