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Literature DB >> 1455506

G proteins.

Abstract

The family of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) serves an essential role in transducing receptor-generated signals across the plasma membrane. Recent findings reveal unexpected functional roles for individual G protein subunits. Thus, GTP-binding alpha-subunits and the beta gamma-subunit complex can influence the activity of effector molecules independently or simultaneously, either synergistically or in opposition, to elicit a complex constellation of cellular events.

Entities: Chemical

Mesh：

Substances：
GTP-Binding Proteins

Year: 1992 PMID： 1455506 DOI： 10.1016/0968-0004(92)90005-t

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

222 in total

1. Arabidopsis thaliana 'extra-large GTP-binding protein' (AtXLG1): a new class of G-protein.

Authors: Y R Lee; S M Assmann
Journal: Plant Mol Biol Date: 1999-05 Impact factor: 4.076

2. Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca(2+) channel modulation in sympathetic neurons.

Authors: S W Jeong; S R Ikeda
Journal: Proc Natl Acad Sci U S A Date: 2000-01-18 Impact factor: 11.205

3. Activation of phosphatidylinositol-3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural progenitor cells.

Authors: B S Li; W Ma; L Zhang; J L Barker; D A Stenger; H C Pant
Journal: J Neurosci Date: 2001-03-01 Impact factor: 6.167

4. Endogenous regulators of G protein signaling proteins regulate presynaptic inhibition at rat hippocampal synapses.

Authors: H Chen; N A Lambert
Journal: Proc Natl Acad Sci U S A Date: 2000-11-07 Impact factor: 11.205

5. G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses.

Authors: Alex J Straiker; Catherine R Borden; Jane M Sullivan
Journal: J Neurosci Date: 2002-04-01 Impact factor: 6.167

G proteins.

1. Arabidopsis thaliana 'extra-large GTP-binding protein' (AtXLG1): a new class of G-protein.

2. Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca(2+) channel modulation in sympathetic neurons.

3. Activation of phosphatidylinositol-3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural progenitor cells.

4. Endogenous regulators of G protein signaling proteins regulate presynaptic inhibition at rat hippocampal synapses.

5. G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses.

Review 6. Evolution of the membrane guanylate cyclase transduction system.

7. Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach.

8. Gamma 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate.

9. Regulation of L-type Ca2+ channels in rabbit portal vein by G protein alphas and betagamma subunits.

10. Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum.