Literature DB >> 20520638

The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis.

P Burda1, P Laslo, T Stopka.   

Abstract

Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20520638     DOI： 10.1038/leu.2010.104

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  60 in total

1.  Stability and multiattractor dynamics of a toggle switch based on a two-stage model of stochastic gene expression.

Authors:  Michael Strasser; Fabian J Theis; Carsten Marr
Journal:  Biophys J       Date:  2012-01-03       Impact factor: 4.033

2.  Identification and characterization of CCAAT enhancer-binding protein (C/EBP) as a transcriptional activator for Epstein-Barr virus oncogene latent membrane protein 1.

Authors:  Chieko Noda; Takayuki Murata; Teru Kanda; Hironori Yoshiyama; Atsuko Sugimoto; Daisuke Kawashima; Shinichi Saito; Hiroki Isomura; Tatsuya Tsurumi
Journal:  J Biol Chem       Date:  2011-10-19       Impact factor: 5.157

3.  The ERGonomics of hematopoietic stem cell self-renewal.

Authors:  Scott A Lacadie; Leonard I Zon
Journal:  Genes Dev       Date:  2011-02-15       Impact factor: 11.361

4.  Acute myeloid leukemia with expanded erythropoiesis.

Authors:  Anna Porwit; James W Vardiman
Journal:  Haematologica       Date:  2011-09       Impact factor: 9.941

Review 5.  The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?

Authors:  A Vilborg; C Bersani; M T Wilhelm; K G Wiman
Journal:  Cell Death Differ       Date:  2011-03-11       Impact factor: 15.828

Review 6.  Role of RUNX1 in hematological malignancies.

Authors:  Raman Sood; Yasuhiko Kamikubo; Paul Liu
Journal:  Blood       Date:  2017-02-08       Impact factor: 22.113

7.  A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation.

Authors:  Clyde A Campbell; Oksana Fursova; Xiaoyi Cheng; Elizabeth Snella; Abbigail McCune; Liangdao Li; Barbara Solchenberger; Bettina Schmid; Debashis Sahoo; Mark Morton; David Traver; Raquel Espín-Palazón
Journal:  Blood Adv       Date:  2021-02-09

8.  A network including PU.1, Vav1 and miR-142-3p sustains ATRA-induced differentiation of acute promyelocytic leukemia cells - a short report.

Authors:  Silvia Grassilli; Ervin Nika; Elisabetta Lambertini; Federica Brugnoli; Roberta Piva; Silvano Capitani; Valeria Bertagnolo
Journal:  Cell Oncol (Dordr)       Date:  2016-08-01       Impact factor: 6.730

9.  The role of tumor suppressor p15Ink4b in the regulation of hematopoietic progenitor cell fate.

Authors:  R Humeniuk; M Rosu-Myles; J Fares; R Koller; J Bies; L Wolff
Journal:  Blood Cancer J       Date:  2013-01-04       Impact factor: 11.037

10.  Induction of a hemogenic program in mouse fibroblasts.

Authors:  Carlos-Filipe Pereira; Betty Chang; Jiajing Qiu; Xiaohong Niu; Dmitri Papatsenko; Caroline E Hendry; Neil R Clark; Aya Nomura-Kitabayashi; Jason C Kovacic; Avi Ma'ayan; Christoph Schaniel; Ihor R Lemischka; Kateri Moore
Journal:  Cell Stem Cell       Date:  2013-06-13       Impact factor: 24.633
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.