| Literature DB >> 20513082 |
Jack Cuzick1, Laurence Ambroisine, Louise Cadman, Janet Austin, Linda Ho, George Terry, Stuart Liddle, Roberto Dina, Julie McCarthy, Hilary Buckley, Christine Bergeron, W P Soutter, Deirdre Lyons, Anne Szarewski.
Abstract
HPV DNA testing is known to be much more sensitive than cytology, but less specific. A range of HPV and related tests in 858 women referred for colposcopy because of an abnormal smear were evaluated to compare the performances of these tests. This article compared the Abbott test to other tests which had been previously evaluated. This test was a real true test for 14 high-risk HPV types. The Abbott test was found to be highly sensitive for cervical intraepithelial neoplasia grade 3 or worse (CIN3+) (98.9%) with a specificity of 31.5%. These numbers were comparable with the Qiagen HC2 test, the Roche Linear Array and Amplicor tests, and the Gen-Probe APTIMA test. Differences between these tests appeared to be related mostly to the choice of cutoff level. An added feature of the Abbott test was the provision of type specific results for HPV 16 and 18. (c) 2010 Wiley-Liss, Inc.Entities:
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Year: 2010 PMID： 20513082 DOI： 10.1002/jmv.21801
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327