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Literature DB >> 20511419

Antibiotic resistance markers for genetic manipulations of Leptospira spp.

Dante Poggi¹, Priscila Oliveira de Giuseppe, Mathieu Picardeau.

Abstract

We measured the frequency of appearance of spontaneous mutants resistant to gentamicin, kanamycin, streptomycin, and spectinomycin in saprophytic and pathogenic Leptospira strains. The mutations responsible for the spontaneous resistance to streptomycin and spectinomycin were identified in the rpsL and rrs genes, respectively. We also generated a gentamicin resistance cassette that allows the use of a third selectable marker in leptospires. These results may facilitate further advances in gene transfer systems in Leptospira spp.

Entities: Chemical

Mesh：

Substances：
Anti-Bacterial Agents

Year: 2010 PMID： 20511419 PMCID： PMC2901752 DOI： 10.1128/AEM.00775-10

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

22 in total

1. An aberrant protein synthesis activity is linked with antibiotic overproduction in rpsL mutants of Streptomyces coelicolor A3(2).

Authors: Yoshiko Okamoto-Hosoya; Takeshi Hosaka; Kozo Ochi
Journal: Microbiology (Reading) Date: 2003-11 Impact factor: 2.777

2. Mutations conferring aminoglycoside and spectinomycin resistance in Borrelia burgdorferi.

Authors: Daniel Criswell; Virginia L Tobiason; J Stephen Lodmell; D Scott Samuels
Journal: Antimicrob Agents Chemother Date: 2006-02 Impact factor: 5.191

Review 3. Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen.

Authors: Albert I Ko; Cyrille Goarant; Mathieu Picardeau
Journal: Nat Rev Microbiol Date: 2009-10 Impact factor: 60.633

Review 4. Counterselectable markers: untapped tools for bacterial genetics and pathogenesis.

Authors: J M Reyrat; V Pelicic; B Gicquel; R Rappuoli
Journal: Infect Immun Date: 1998-09 Impact factor: 3.441

5. Spectinomycin resistance in Neisseria spp. due to mutations in 16S rRNA.

Authors: M Galimand; G Gerbaud; P Courvalin
Journal: Antimicrob Agents Chemother Date: 2000-05 Impact factor: 5.191

6. Random insertional mutagenesis of Leptospira interrogans, the agent of leptospirosis, using a mariner transposon.

Authors: Pascale Bourhy; Hélène Louvel; Isabelle Saint Girons; Mathieu Picardeau
Journal: J Bacteriol Date: 2005-05 Impact factor: 3.490

7. Broth microdilution susceptibility testing for Leptospira spp.

Authors: Clinton K Murray; Duane R Hospenthal
Journal: Antimicrob Agents Chemother Date: 2004-05 Impact factor: 5.191

8. Construction and complementation of the first auxotrophic mutant in the spirochaete Leptospira meyeri.

Authors: Hélène Bauby; Isabelle Saint Girons; Mathieu Picardeau
Journal: Microbiology Date: 2003-03 Impact factor: 2.777

9. The molecular basis for rRNA-dependent spectinomycin resistance in Nicotiana chloroplasts.

Authors: H Fromm; M Edelman; D Aviv; E Galun
Journal: EMBO J Date: 1987-11 Impact factor: 11.598

10. Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis.

Authors: Mathieu Picardeau; Dieter M Bulach; Christiane Bouchier; Richard L Zuerner; Nora Zidane; Peter J Wilson; Sophie Creno; Elizabeth S Kuczek; Simona Bommezzadri; John C Davis; Annette McGrath; Matthew J Johnson; Caroline Boursaux-Eude; Torsten Seemann; Zoé Rouy; Ross L Coppel; Julian I Rood; Aurélie Lajus; John K Davies; Claudine Médigue; Ben Adler
Journal: PLoS One Date: 2008-02-13 Impact factor: 3.240

11 in total

1. A replicative plasmid vector allows efficient complementation of pathogenic Leptospira strains.

Authors: Christopher J Pappas; Nadia Benaroudj; Mathieu Picardeau
Journal: Appl Environ Microbiol Date: 2015-02-27 Impact factor: 4.792

2. Development of a modified gentamicin resistance cassette for genetic manipulation of the oral spirochete Treponema denticola.

Authors: Jiang Bian; J Christopher Fenno; Chunhao Li
Journal: Appl Environ Microbiol Date: 2012-01-13 Impact factor: 4.792

3. High-throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants During Golden Syrian Hamster Infection.

Authors: Kristel Lourdault; James Matsunaga; Karen V Evangelista; David A Haake
Journal: J Vis Exp Date: 2017-12-18 Impact factor: 1.355

4. Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants.

Authors: Adrien Fabre; Monica Oleastro; Alexandra Nunes; Andrea Santos; Elodie Sifré; Astrid Ducournau; Lucie Bénéjat; Alice Buissonnière; Pauline Floch; Francis Mégraud; Véronique Dubois; Philippe Lehours
Journal: J Clin Microbiol Date: 2018-08-27 Impact factor: 5.948

5. The sigma factor σ⁵⁴ is required for the long-term survival of Leptospira biflexa in water.

Authors: Jun-Jie Zhang; Wei-Lin Hu; Youyun Yang; Hongxia Li; Mathieu Picardeau; Jie Yan; X Frank Yang
Journal: Mol Microbiol Date: 2018-04-06 Impact factor: 3.501

6. Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin.

Authors: Cláudio Pereira Figueira; Julio Croda; Henry A Choy; David A Haake; Mitermayer G Reis; Albert I Ko; Mathieu Picardeau
Journal: BMC Microbiol Date: 2011-06-09 Impact factor: 3.605

10. Discovery of a leptospirosis cluster amidst a pneumonic plague outbreak in a miners' camp in the Democratic Republic of the Congo.

Authors: Eric Bertherat; Melissa J Mueller; Jean-Christophe Shako; Mathieu Picardeau
Journal: Int J Environ Res Public Health Date: 2014-02-07 Impact factor: 3.390