| Literature DB >> 20510262 |
Myron J Levin1, Anne A Gershon, Robert H Dworkin, Marc Brisson, Lawrence Stanberry.
Abstract
Impairment of varicella zoster virus (VZV)-specific cell-mediated immunity, including impairment due to immunosenescence, is associated with an increased risk of developing herpes zoster (HZ), whereas levels of anti-VZV antibodies do not correlate with HZ risk. This crucial role of VZV-specific cell-mediated immunity suggests that boosting these responses by vaccination will be an effective strategy for reducing the burden of HZ. Other strategies focus on preventing the major complication of HZ--post-herpetic neuralgia. These strategies include pre-emptive treatment with drugs such as tricyclic antidepressants, anticonvulsants and analgesics. 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20510262 PMCID： PMC5391038 DOI： 10.1016/S1386-6532(10)70004-4
Source DB: PubMed Journal: J Clin Virol ISSN： 1386-6532 Impact factor: 3.168