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Literature DB >> 2050657

Study of the interaction of cadmium with membrane-bound succinate dehydrogenase.

D Jay¹, R Zamorano, E Muñoz, R Gleason, J L Boldu.

Abstract

Cadmium ions inhibit membrane-bound succinate dehydrogenase with a second-order rate constant of 10.42 mM-1 s-1 at pH 7.35 and 25 degrees C. Succinate and malonate protect the enzyme against cadmium ion inhibition. The protection pattern exerted by succinate and malonate suggests that the group modified by cadmium is located at the active site. The pH curve of inactivation by Cd2+ indicates the involvement of an amino acid residue with pKa of 7.23.

Entities: Chemical Gene

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Year: 1991 PMID： 2050657 DOI： 10.1007/bf00762229

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

33 in total

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Journal: Biochem J Date: 1938-10 Impact factor: 3.857

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Authors: L Wojtczak; A B Wojtczak; L Ernster
Journal: Biochim Biophys Acta Date: 1969-09-30

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Authors: A D Vinogradov
Journal: Biokhimiia Date: 1986-12

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Authors: B A Ackrell; E B Kearney; T P Singer
Journal: Methods Enzymol Date: 1978 Impact factor: 1.600

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Authors: W C Kenney
Journal: J Biol Chem Date: 1975-04-25 Impact factor: 5.157

8. Nucleotide sequence encoding the flavoprotein and iron-sulfur protein subunits of the Bacillus subtilis PY79 succinate dehydrogenase complex.

Authors: M K Phillips; L Hederstedt; S Hasnain; L Rutberg; J R Guest
Journal: J Bacteriol Date: 1987-02 Impact factor: 3.490

9. Modification of TPN-dependent isocitrate dehydrogenase by the 2', 3'-dialdehyde derivatives of TPNH and TPN.

Authors: M T Mas; R F Colman
Journal: J Biol Chem Date: 1983-08-10 Impact factor: 5.157

10. Studies on the reactivity of the essential sulfhydryl groups as a conformational probe for the fatty acid synthetase of chicken liver. Inactivation by 5,5'-dithiobis-(2-nitrobenzoic acid) and intersubunit cross-linking of the inactivated enzyme.

Authors: W X Tian; R Y Hsu; Y S Wang
Journal: J Biol Chem Date: 1985-09-15 Impact factor: 5.157

6 in total

Study of the interaction of cadmium with membrane-bound succinate dehydrogenase.

1. DETERNATION OF CO-FACTOR DISSOCIATION CONSTANTS FROM THE KINETICS OF INHIBITION OF ENZYMES.

2. Studies on succinic dehydrogenase. IV. Activation of the beef heart enzyme.

3. The influence of thiol groups in the activity of dehydrogenases. II: With an addendum on the location of dehydrogenases in muscle.

4. The inhibition of succinate dehydrogenase by oxalacetate.

Review 5. [Succinate-ubiquinone reductase site of the respiratory chain].

6. Mammalian succinate dehydrogenase.

7. The reaction of N-ethylmaleimide at the active site of succinate dehydrogenase.

8. Nucleotide sequence encoding the flavoprotein and iron-sulfur protein subunits of the Bacillus subtilis PY79 succinate dehydrogenase complex.

9. Modification of TPN-dependent isocitrate dehydrogenase by the 2', 3'-dialdehyde derivatives of TPNH and TPN.

10. Studies on the reactivity of the essential sulfhydryl groups as a conformational probe for the fatty acid synthetase of chicken liver. Inactivation by 5,5'-dithiobis-(2-nitrobenzoic acid) and intersubunit cross-linking of the inactivated enzyme.

1. Comparative transcriptome analysis in the hepatopancreas of Helice tientsinensis exposed to the toxic metal cadmium.

2. Bivalent metal ions modulate Cd2+ effects on isolated rat liver mitochondria.

3. Assessment of toxicity using dehydrogenases activity and mathematical modeling.

4. Inhibition of membrane-bound succinate dehydrogenase by fluorescamine.

Review 5. Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain.

6. Effect of Chlorella vulgaris intake on cadmium detoxification in rats fed cadmium.