Literature DB >> 20504030

Is halogen bonding the basis for iodothyronine deiodinase activity?

Craig A Bayse1, Erin R Rafferty.   

Abstract

Density functional theory studies of S...X and Se...X (X = Br, I) halogen-bonding interactions are used to interpret the selection of selenium and iodine for thyroid hormone signaling. A new mechanism for dehalogenation in terms of halogen bonding is proposed. The activation barriers for deiodination of an aromatic iodide by MeSeH and MeSH (17.6 and 19.8 kcal/mol) are consistent with the relative rates of deiodination by iodothyronine deiodinase and its cysteine mutant.

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Year:  2010        PMID： 20504030     DOI： 10.1021/ic100711n

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  11 in total

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3.  Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase.

Authors:  Jonathan R Chekan; Ga Young Lee; Abrahim El Gamal; Trevor N Purdy; K N Houk; Bradley S Moore
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4.  A DFT investigation of a bulky biomimetic model catalyzing the 5'-outer ring deiodination of thyroxine.

Authors:  Mariagrazia Fortino; Tiziana Marino; Nino Russo; Emilia Sicilia
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5.  Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.

Authors:  Ulrich Schweizer; Christine Schlicker; Doreen Braun; Josef Köhrle; Clemens Steegborn
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-07       Impact factor: 11.205

6.  Halogen Bonding Interactions of Polychlorinated Biphenyls and the Potential for Thyroid Disruption.

Authors:  Eric S Marsan; Craig A Bayse
Journal:  Chemistry       Date:  2020-02-25       Impact factor: 5.236

Review 7.  Design of Radioiodinated Pharmaceuticals: Structural Features Affecting Metabolic Stability towards in Vivo Deiodination.

Authors:  Lorenzo Cavina; Dion van der Born; Peter H M Klaren; Martin C Feiters; Otto C Boerman; Floris P J T Rutjes
Journal:  European J Org Chem       Date:  2017-04-26

Review 8.  The Halogen Bond.

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Review 9.  A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity.

Authors:  Eric S Marsan; Craig A Bayse
Journal:  Molecules       Date:  2020-03-14       Impact factor: 4.411

10.  Thyroxine binding to type III iodothyronine deiodinase.

Authors:  Craig A Bayse; Eric S Marsan; Jenna R Garcia; Alexis T Tran-Thompson
Journal:  Sci Rep       Date:  2020-09-21       Impact factor: 4.379
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