OBJECTIVE: To quantify the differences in risk factors influencing total hip replacement (THR) and total knee replacement (TKR) based on the presence versus absence of multiple interphalangeal nodes in 2 or more rays of the fingers of each hand in patients with large joint osteoarthritis (OA). METHODS: A group of 3,800 patients with large joint OA who underwent total joint replacement (1,201 of whom had the nodal phenotype) and 1,906 control subjects from 2 case-control studies and a population-based cohort in the UK were studied. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for the risk of total joint replacement in association with age, sex, body mass index (BMI), height, and prevalence of the T allele in the GDF5 rs143383 polymorphism. ORs for total joint replacement were compared between cases of nodal OA and cases of non-nodal OA and between patients who underwent TKR and those who underwent THR. RESULTS: Age, sex, and BMI had significantly higher ORs for an association with total joint replacement in nodal OA cases than in non-nodal OA cases. The GDF5 polymorphism was significantly associated with THR in cases of nodal OA, but not in cases of non-nodal OA, and increased height was a risk factor for THR in non-nodal OA cases only. Female sex was a protective risk factor for TKR in non-nodal OA cases (OR 0.60, 95% CI 0.52-0.70) but was predisposing for TKR in the nodal form of OA (OR 1.83, 95% CI 1.49-2.26). The nodal phenotype was associated with a significantly higher risk of undergoing both THR and TKR (OR 1.46, 95% CI 1.09-1.94) and also a significantly higher risk of bilateral TKR (OR 1.70, 95% CI 1.37-2.11), but, paradoxically, was associated with a lower risk of bilateral THR (OR 0.72, 95% CI 0.56-0.91). CONCLUSION: Nodal and non-nodal forms of large joint OA have significantly different risk factors and outcomes, indicating a different etiology for the 2 forms of OA. With regard to the likelihood of undergoing THR, this appears to be, at least in part, genetically determined.
OBJECTIVE: To quantify the differences in risk factors influencing total hip replacement (THR) and total knee replacement (TKR) based on the presence versus absence of multiple interphalangeal nodes in 2 or more rays of the fingers of each hand in patients with large joint osteoarthritis (OA). METHODS: A group of 3,800 patients with large joint OA who underwent total joint replacement (1,201 of whom had the nodal phenotype) and 1,906 control subjects from 2 case-control studies and a population-based cohort in the UK were studied. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for the risk of total joint replacement in association with age, sex, body mass index (BMI), height, and prevalence of the T allele in the GDF5 rs143383 polymorphism. ORs for total joint replacement were compared between cases of nodal OA and cases of non-nodal OA and between patients who underwent TKR and those who underwent THR. RESULTS: Age, sex, and BMI had significantly higher ORs for an association with total joint replacement in nodal OA cases than in non-nodal OA cases. The GDF5 polymorphism was significantly associated with THR in cases of nodal OA, but not in cases of non-nodal OA, and increased height was a risk factor for THR in non-nodal OA cases only. Female sex was a protective risk factor for TKR in non-nodal OA cases (OR 0.60, 95% CI 0.52-0.70) but was predisposing for TKR in the nodal form of OA (OR 1.83, 95% CI 1.49-2.26). The nodal phenotype was associated with a significantly higher risk of undergoing both THR and TKR (OR 1.46, 95% CI 1.09-1.94) and also a significantly higher risk of bilateral TKR (OR 1.70, 95% CI 1.37-2.11), but, paradoxically, was associated with a lower risk of bilateral THR (OR 0.72, 95% CI 0.56-0.91). CONCLUSION: Nodal and non-nodal forms of large joint OA have significantly different risk factors and outcomes, indicating a different etiology for the 2 forms of OA. With regard to the likelihood of undergoing THR, this appears to be, at least in part, genetically determined.
Authors: Amanda E Nelson; Jordan B Renner; Todd A Schwartz; Virginia B Kraus; Charles G Helmick; Joanne M Jordan Journal: Arthritis Rheum Date: 2011-12
Authors: Unnur Styrkarsdottir; Gudmar Thorleifsson; Hafdis T Helgadottir; Nils Bomer; Sarah Metrustry; S Bierma-Zeinstra; Annelieke M Strijbosch; Evangelos Evangelou; Deborah Hart; Marian Beekman; Aslaug Jonasdottir; Asgeir Sigurdsson; Finnur F Eiriksson; Margret Thorsteinsdottir; Michael L Frigge; Augustine Kong; Sigurjon A Gudjonsson; Olafur T Magnusson; Gisli Masson; Albert Hofman; Nigel K Arden; Thorvaldur Ingvarsson; Stefan Lohmander; Margreet Kloppenburg; Fernando Rivadeneira; Rob G H H Nelissen; Tim Spector; Andre Uitterlinden; P Eline Slagboom; Unnur Thorsteinsdottir; Ingileif Jonsdottir; Ana M Valdes; Ingrid Meulenbelt; Joyce van Meurs; Helgi Jonsson; Kari Stefansson Journal: Nat Genet Date: 2014-04-13 Impact factor: 38.330
Authors: H J M Kerkhof; I Meulenbelt; T Akune; N K Arden; A Aromaa; S M A Bierma-Zeinstra; A Carr; C Cooper; J Dai; M Doherty; S A Doherty; D Felson; A Gonzalez; A Gordon; A Harilainen; D J Hart; V B Hauksson; M Heliovaara; A Hofman; S Ikegawa; T Ingvarsson; Q Jiang; H Jonsson; I Jonsdottir; H Kawaguchi; M Kloppenburg; U M Kujala; N E Lane; P Leino-Arjas; L S Lohmander; F P Luyten; K N Malizos; M Nakajima; M C Nevitt; H A P Pols; F Rivadeneira; D Shi; E Slagboom; T D Spector; K Stefansson; A Sudo; A Tamm; A E Tamm; A Tsezou; A Uchida; A G Uitterlinden; J M Wilkinson; N Yoshimura; A M Valdes; J B J van Meurs Journal: Osteoarthritis Cartilage Date: 2010-11-06 Impact factor: 6.576
Authors: K Panoutsopoulou; L Southam; K S Elliott; N Wrayner; G Zhai; C Beazley; G Thorleifsson; N K Arden; A Carr; K Chapman; P Deloukas; M Doherty; A McCaskie; W E R Ollier; S H Ralston; T D Spector; A M Valdes; G A Wallis; J M Wilkinson; E Arden; K Battley; H Blackburn; F J Blanco; S Bumpstead; L A Cupples; A G Day-Williams; K Dixon; S A Doherty; T Esko; E Evangelou; D Felson; J J Gomez-Reino; A Gonzalez; A Gordon; R Gwilliam; B V Halldorsson; V B Hauksson; A Hofman; S E Hunt; J P A Ioannidis; T Ingvarsson; I Jonsdottir; H Jonsson; R Keen; H J M Kerkhof; M G Kloppenburg; N Koller; N Lakenberg; N E Lane; A T Lee; A Metspalu; I Meulenbelt; M C Nevitt; F O'Neill; N Parimi; S C Potter; I Rego-Perez; J A Riancho; K Sherburn; P E Slagboom; K Stefansson; U Styrkarsdottir; M Sumillera; D Swift; U Thorsteinsdottir; A Tsezou; A G Uitterlinden; J B J van Meurs; B Watkins; M Wheeler; S Mitchell; Y Zhu; J M Zmuda; E Zeggini; J Loughlin Journal: Ann Rheum Dis Date: 2010-12-21 Impact factor: 19.103
Authors: Eleftheria Zeggini; Kalliope Panoutsopoulou; Lorraine Southam; Nigel W Rayner; Aaron G Day-Williams; Margarida C Lopes; Vesna Boraska; Tonu Esko; Evangelos Evangelou; Albert Hoffman; Jeanine J Houwing-Duistermaat; Thorvaldur Ingvarsson; Ingileif Jonsdottir; Helgi Jonnson; Hanneke J Kerkhof; Margreet Kloppenburg; Steffan D Bos; Massimo Mangino; Sarah Metrustry; P Eline Slagboom; Gudmar Thorleifsson; Emma V A Raine; Madhushika Ratnayake; Michelle Ricketts; Claude Beazley; Hannah Blackburn; Suzannah Bumpstead; Katherine S Elliott; Sarah E Hunt; Simon C Potter; So-Youn Shin; Vijay K Yadav; Guangju Zhai; Kate Sherburn; Kate Dixon; Elizabeth Arden; Nadim Aslam; Phillippa-kate Battley; Ian Carluke; Sally Doherty; Andrew Gordon; John Joseph; Richard Keen; Nicola C Koller; Sheryl Mitchell; Fiona O'Neill; Ellen Paling; Mike R Reed; Fernando Rivadeneira; Diane Swift; Kirsten Walker; Bridget Watkins; Maggie Wheeler; Fraser Birrell; John P A Ioannidis; Ingrid Meulenbelt; Andres Metspalu; Ashok Rai; Donald Salter; Kari Stefansson; Unnur Stykarsdottir; André G Uitterlinden; Joyce B J van Meurs; Kay Chapman; Panos Deloukas; William E R Ollier; Gillian A Wallis; Nigel Arden; Andrew Carr; Michael Doherty; Andrew McCaskie; J Mark Willkinson; Stuart H Ralston; Ana M Valdes; Tim D Spector; John Loughlin Journal: Lancet Date: 2012-07-03 Impact factor: 79.321
Authors: Andrew J Metcalfe; Maria L E Andersson; Rhian Goodfellow; Carina A Thorstensson Journal: BMC Musculoskelet Disord Date: 2012-08-22 Impact factor: 2.362
Authors: Katherine S Elliott; Kay Chapman; Aaron Day-Williams; Kalliope Panoutsopoulou; Lorraine Southam; Cecilia M Lindgren; Nigel Arden; Nadim Aslam; Fraser Birrell; Ian Carluke; Andrew Carr; Panos Deloukas; Michael Doherty; John Loughlin; Andrew McCaskie; William E R Ollier; Ashok Rai; Stuart Ralston; Mike R Reed; Timothy D Spector; Ana M Valdes; Gillian A Wallis; Mark Wilkinson; Eleftheria Zeggini Journal: Ann Rheum Dis Date: 2012-09-06 Impact factor: 19.103