Literature DB >> 20499322

Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry.

Xi Shao1, Xiaoxin Chen, Vladimir Badmaev, Chi-Tang Ho, Shengmin Sang.   

Abstract

Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the present study, we identified nine novel mouse urinary pterostilbene metabolites, pterostilbene glucuronide, pterostilbene sulfate, mono-demethylated pterostilbene glucuronide, mono-demethylated pterostilbene sulfate, mono-hydroxylated pterostilbene, mono-hydroxylated pterostilbene glucuronide, mono-hydroxylated pterostilbene sulfate, and mono-hydroxylated pterostilbene glucuronide sulfate, using liquid chromatography/atmospheric pressure chemical ionization and electrospray ionization tandem mass spectrometry. The structures of these metabolites were confirmed by analyzing the MS(n) (n = 1-3) spectra. To our knowledge, this is the first report of the identification of urinary metabolites of pterostilbene in mice. Copyright 2010 John Wiley & Sons, Ltd.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20499322     DOI： 10.1002/rcm.4579

Source DB:  PubMed          Journal:  Rapid Commun Mass Spectrom        ISSN： 0951-4198            Impact factor:   2.419


  13 in total

1.  Metabolism of [6]-shogaol in mice and in cancer cells.

Authors:  Huadong Chen; Lishuang Lv; Dominique Soroka; Renaud F Warin; Tiffany A Parks; Yuhui Hu; Yingdong Zhu; Xiaoxin Chen; Shengmin Sang
Journal:  Drug Metab Dispos       Date:  2012-01-13       Impact factor: 3.922

2.  Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.

Authors:  Huadong Chen; Dominique N Soroka; Yuhui Hu; Xiaoxin Chen; Shengmin Sang
Journal:  Mol Nutr Food Res       Date:  2013-01-16       Impact factor: 5.914

3.  Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells.

Authors:  Min-Tsang Hsieh; Li-Jiau Huang; Tian-Shung Wu; Hui-Yi Lin; Susan L Morris-Natschke; Kuo-Hsiung Lee; Sheng-Chu Kuo
Journal:  Bioorg Med Chem       Date:  2018-06-08       Impact factor: 3.641

4.  6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cells.

Authors:  Lishuang Lv; Huadong Chen; Dominique Soroka; Xiaoxin Chen; TinChung Leung; Shengmin Sang
Journal:  J Agric Food Chem       Date:  2012-11-06       Impact factor: 5.279

5.  Differences in the glucuronidation of resveratrol and pterostilbene: altered enzyme specificity and potential gender differences.

Authors:  Ryan W Dellinger; Angela M Gomez Garcia; Frank L Meyskens
Journal:  Drug Metab Pharmacokinet       Date:  2013-08-20       Impact factor: 3.614

6.  De novo biosynthesis of pterostilbene in an Escherichia coli strain using a new resveratrol O-methyltransferase from Arabidopsis.

Authors:  Kyung Taek Heo; Sun-Young Kang; Young-Soo Hong
Journal:  Microb Cell Fact       Date:  2017-02-15       Impact factor: 5.328

7.  Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals.

Authors:  Muhammed Majeed; Sarang Bani; Sankaran Natarajan; Anjali Pandey; Naveed S
Journal:  PLoS One       Date:  2017-03-03       Impact factor: 3.240

Review 8.  Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation.

Authors:  Ruth Hornedo-Ortega; Ana B Cerezo; Rocío M de Pablos; Stéphanie Krisa; Tristan Richard; M Carmen García-Parrilla; Ana M Troncoso
Journal:  Front Cell Neurosci       Date:  2018-10-23       Impact factor: 5.505

Review 9.  Role of Natural Stilbenes in the Prevention of Cancer.

Authors:  J Antoni Sirerol; María L Rodríguez; Salvador Mena; Miguel A Asensi; José M Estrela; Angel L Ortega
Journal:  Oxid Med Cell Longev       Date:  2015-12-21       Impact factor: 6.543

Review 10.  Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol.

Authors:  Yeju Liu; Yuyang You; Juan Lu; Xi Chen; Zhihong Yang
Journal:  Molecules       Date:  2020-11-06       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.