| Literature DB >> 20494325 |
Alberto Ascherio1, Kassandra L Munger, K Claire Simon.
Abstract
The hypothesis that adequate vitamin D nutrition can contribute to the prevention of multiple sclerosis (MS) was originally proposed to explain the geographical distribution of MS, but only recently has the relation between various measures of vitamin D (eg, sun exposure, dietary sources, and serum concentrations of 25-hydroxyvitamin D) and risk of developing MS been rigorously investigated. Overall, the results of these studies support a protective effect of vitamin D, but there are uncertainties and many unanswered questions, including how vitamin D exerts a protective effect, how genetic variations modify the effect, and whether vitamin D can influence the course of MS progression. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
Mesh:
Substances:
Year: 2010 PMID: 20494325 DOI: 10.1016/S1474-4422(10)70086-7
Source DB: PubMed Journal: Lancet Neurol ISSN: 1474-4422 Impact factor: 44.182