Literature DB >> 20488590

Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives.

Mohamed Abdel-Aziz1, Hamdy M Abdel-Rahman.   

Abstract

A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide-hydrazone derivatives 3a-l were less active than pyrazinamide. In contrast, the N(4)-ethyl-N(1)-pyrazinoyl-thiosemicarbazide 4 showed the highest activity against M. tuberculosis H(37)Rv (IC(90) = 16.87 microg/mL). Details of the structure-activity and structure-cytotoxicity relationships are discussed. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20488590     DOI： 10.1016/j.ejmech.2010.04.025

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  4 in total

1.  Synthesis, characterization, and tuberculostatic activity of novel 2-(4-nitrobenzoyl)hydrazinecarbodithioic acid derivatives.

Authors:  Katarzyna Gobis; Henryk Foks; Ewa Augustynowicz-Kopec; Agnieszka Napiorkowska; Malgorzata Szczesio; Andrzej Olczak; Marek L Glowka
Journal:  Monatsh Chem       Date:  2012-01-24       Impact factor: 1.451

2.  Synthesis, structure, and tuberculostatic activity of dimethyl benzoylcarbonohydrazonodithioates.

Authors:  Katarzyna Gobis; Henryk Foks; Zofia Zwolska; Ewa Augustynowicz-Kopeć; Marek L Główka; Andrzej Olczak; Michał Sabisz
Journal:  Monatsh Chem       Date:  2011-08-16       Impact factor: 1.451

3.  Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.

Authors:  Amany M Ghanim; Samar Rezq; Tarek S Ibrahim; Damian G Romero; Hend Kothayer
Journal:  Eur J Med Chem       Date:  2021-04-20       Impact factor: 7.088

4.  Facile Synthesis of 5-Aryl-N-(pyrazin-2-yl)thiophene-2-carboxamides via Suzuki Cross-Coupling Reactions, Their Electronic and Nonlinear Optical Properties through DFT Calculations.

Authors:  Gulraiz Ahmad; Nasir Rasool; Adeel Mubarik; Ameer Fawad Zahoor; Muhammad Ali Hashmi; Muhammad Zubair; Muhammad Bilal; Mohamed Hussien; Muhammad Saeed Akhtar; Sajjad Haider
Journal:  Molecules       Date:  2021-12-02       Impact factor: 4.411
  4 in total

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