BACKGROUND/AIMS: This study evaluated the prevention by lamivudine of hepatocellular carcinoma (HCC) in chronic hepatitis B patients. METHODS: Lamivudine therapy was administered to 879 of the 2,511 patients who satisfied our analysis inclusion criteria. A Cox regression model revealed that four factors increased the prevalence of HCC: gender (females; OR=0.53, p=0.006), age (>/=40 years; OR=4.64, p<0.001), platelet count (>/=100x10(3)/mm(3); OR=0.35, p<0.001), and alcohol consumption (>/=80 g/day; OR=1.79, p=0.004). Five hundred and eighty-nine patients in the lamivudine-treated group and 589 patients in the control group were selected for a matched case-control study. The mean follow-up periods were 2.8 and 5.1 years in the lamivudine-treated and control groups, respectively. RESULTS: HCC occurred in 10 patients (1.7%) of the lamivudine group, with an incidence rate of 0.61% patients/year, and in 65 patients (11.0%) of the control group, with an incidence rate of 2.16% patients/year. The cumulative incidence of HCC was lower in the lamivudine group than in the control group (p=0.0117, log-rank test). CONCLUSIONS: Lamivudine can reduce the incidence of HCC in patients suffering from chronic hepatitis B.
BACKGROUND/AIMS: This study evaluated the prevention by lamivudine of hepatocellular carcinoma (HCC) in chronic hepatitis Bpatients. METHODS:Lamivudine therapy was administered to 879 of the 2,511 patients who satisfied our analysis inclusion criteria. A Cox regression model revealed that four factors increased the prevalence of HCC: gender (females; OR=0.53, p=0.006), age (>/=40 years; OR=4.64, p<0.001), platelet count (>/=100x10(3)/mm(3); OR=0.35, p<0.001), and alcohol consumption (>/=80 g/day; OR=1.79, p=0.004). Five hundred and eighty-nine patients in the lamivudine-treated group and 589 patients in the control group were selected for a matched case-control study. The mean follow-up periods were 2.8 and 5.1 years in the lamivudine-treated and control groups, respectively. RESULTS:HCC occurred in 10 patients (1.7%) of the lamivudine group, with an incidence rate of 0.61% patients/year, and in 65 patients (11.0%) of the control group, with an incidence rate of 2.16% patients/year. The cumulative incidence of HCC was lower in the lamivudine group than in the control group (p=0.0117, log-rank test). CONCLUSIONS:Lamivudine can reduce the incidence of HCC in patients suffering from chronic hepatitis B.
Authors: F Nevens; J Main; P Honkoop; D L Tyrrell; J Barber; M T Sullivan; J Fevery; R A De Man; H C Thomas Journal: Gastroenterology Date: 1997-10 Impact factor: 22.682
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Authors: C L Lai; R N Chien; N W Leung; T T Chang; R Guan; D I Tai; K Y Ng; P C Wu; J C Dent; J Barber; S L Stephenson; D F Gray Journal: N Engl J Med Date: 1998-07-09 Impact factor: 91.245
Authors: Suk Bae Kim; Il Han Song; Young Min Kim; Ran Noh; Ha Yan Kang; Hyang Ie Lee; Hyeon Yoong Yang; An Na Kim; Hee Bok Chae; Sae Hwan Lee; Hong Soo Kim; Tae Hee Lee; Young Woo Kang; Eaum Seok Lee; Seok Hyun Kim; Byung Seok Lee; Heon Young Lee Journal: World J Gastroenterol Date: 2012-12-21 Impact factor: 5.742