BACKGROUND: The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies. OBJECTIVE: We examined whether genetic variations in the FADS gene cluster region interact with dietary intakes of n-3 (omega-3) and n-6 (omega-6) PUFAs to affect plasma total, HDL-, and non-HDL-cholesterol concentrations. DESIGN: Dietary intakes of n-3 and n-6 PUFAs, plasma concentrations of total and HDL cholesterol, and rs174546, rs482548, and rs174570 in the FADS gene cluster region were measured in 3575 subjects in the second survey of the Doetinchem Cohort Study. RESULTS: Significant associations between rs174546 genotypes and total and non-HDL-cholesterol concentrations were observed in the group with a high intake of n-3 PUFAs (> or =0.51% of total energy; P = 0.006 and 0.047, respectively) but not in the low-intake group (P for interaction = 0.32 and 0.51, respectively). The C allele was associated with high total and non-HDL-cholesterol concentrations. Furthermore, the C allele was significantly associated with high HDL-cholesterol concentrations in the group with a high intake of n-6 PUFAs (> or =5.26% of total energy, P = 0.004) but not in the group with a low intake (P for interaction = 0.02). CONCLUSION: Genetic variation in the FADS1 gene potentially interacts with dietary PUFA intakes to affect plasma cholesterol concentrations, which should be investigated further in other studies.
BACKGROUND: The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies. OBJECTIVE: We examined whether genetic variations in the FADS gene cluster region interact with dietary intakes of n-3 (omega-3) and n-6 (omega-6) PUFAs to affect plasma total, HDL-, and non-HDL-cholesterol concentrations. DESIGN: Dietary intakes of n-3 and n-6 PUFAs, plasma concentrations of total and HDL cholesterol, and rs174546, rs482548, and rs174570 in the FADS gene cluster region were measured in 3575 subjects in the second survey of the Doetinchem Cohort Study. RESULTS: Significant associations between rs174546 genotypes and total and non-HDL-cholesterol concentrations were observed in the group with a high intake of n-3 PUFAs (> or =0.51% of total energy; P = 0.006 and 0.047, respectively) but not in the low-intake group (P for interaction = 0.32 and 0.51, respectively). The C allele was associated with high total and non-HDL-cholesterol concentrations. Furthermore, the C allele was significantly associated with high HDL-cholesterol concentrations in the group with a high intake of n-6 PUFAs (> or =5.26% of total energy, P = 0.004) but not in the group with a low intake (P for interaction = 0.02). CONCLUSION: Genetic variation in the FADS1 gene potentially interacts with dietary PUFA intakes to affect plasma cholesterol concentrations, which should be investigated further in other studies.
Authors: Shannon R Porenta; Yi-An Ko; Stephen B Gruber; Bhramar Mukherjee; Ana Baylin; Jianwei Ren; Zora Djuric Journal: Cancer Prev Res (Phila) Date: 2013-09-10
Authors: Dariush Mozaffarian; Edmond K Kabagambe; Catherine O Johnson; Rozenn N Lemaitre; Ani Manichaikul; Qi Sun; Millennia Foy; Lu Wang; Howard Wiener; Marguerite R Irvin; Stephen S Rich; Hongyu Wu; Majken K Jensen; Daniel I Chasman; Audrey Y Chu; Myriam Fornage; Lyn Steffen; Irena B King; Barbara McKnight; Bruce M Psaty; Luc Djoussé; Ida Y-D Chen; Jason H Y Wu; David S Siscovick; Paul M Ridker; Michael Y Tsai; Eric B Rimm; Frank B Hu; Donna K Arnett Journal: Am J Clin Nutr Date: 2014-12-10 Impact factor: 7.045
Authors: Maryam Al-Hilal; Aseel Alsaleh; Zoitsa Maniou; Fiona J Lewis; Wendy L Hall; Thomas A B Sanders; Sandra D O'Dell Journal: J Lipid Res Date: 2012-11-15 Impact factor: 5.922
Authors: Suzanne J Meldrum; Yuchun Li; Guicheng Zhang; Alexandra E M Heaton; Nina D'Vaz; Judith Manz; Eva Reischl; Berthold V Koletzko; Susan L Prescott; Karen Simmer Journal: Eur J Nutr Date: 2017-09-19 Impact factor: 5.614